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CD8+ T cells fail to limit SIV reactivation following ART withdrawal until after viral amplification.
Okoye AA, Duell DD, Fukazawa Y, Varco-Merth B, Marenco A, Behrens H, Chaunzwa M, Selseth AN, Gilbride RM, Shao J, Edlefsen PT, Geleziunas R, Pinkevych M, Davenport MP, Busman-Sahay K, Nekorchuk M, Park H, Smedley J, Axthelm MK, Estes JD, Hansen SG, Keele BF, Lifson JD, Picker LJ. Okoye AA, et al. Among authors: varco merth b. J Clin Invest. 2021 Apr 15;131(8):e141677. doi: 10.1172/JCI141677. J Clin Invest. 2021. PMID: 33630764 Free PMC article.
Evaluating a New Class of AKT/mTOR Activators for HIV Latency Reversing Activity Ex Vivo and In Vivo.
Gramatica A, Schwarzer R, Brantley W, Varco-Merth B, Sperber HS, Hull PA, Montano M, Migueles SA, Rosenthal D, Hogan LE, Johnson JR, Packard TA, Grimmett ZW, Herzig E, Besnard E, Nekorchuk M, Hsiao F, Deeks SG, Snape M, Kiernan B, Roan NR, Lifson JD, Estes JD, Picker LJ, Verdin E, Krogan NJ, Henrich TJ, Connors M, Ott M, Pillai SK, Okoye AA, Greene WC. Gramatica A, et al. Among authors: varco merth b. J Virol. 2021 Mar 25;95(8):e02393-20. doi: 10.1128/JVI.02393-20. Epub 2021 Feb 3. J Virol. 2021. PMID: 33536176 Free PMC article.
Immune inactivation of anti-simian immunodeficiency virus chimeric antigen receptor T cells in rhesus macaques.
Haeseleer F, Fukazawa Y, Park H, Varco-Merth B, Rust BJ, Smedley JV, Eichholz K, Peterson CW, Mason R, Kiem HP, Roederer M, Picker LJ, Okoye AA, Corey L. Haeseleer F, et al. Among authors: varco merth b. Mol Ther Methods Clin Dev. 2021 Jun 24;22:304-319. doi: 10.1016/j.omtm.2021.06.008. eCollection 2021 Sep 10. Mol Ther Methods Clin Dev. 2021. PMID: 34485613 Free PMC article.
Rapamycin limits CD4+ T cell proliferation in simian immunodeficiency virus-infected rhesus macaques on antiretroviral therapy.
Varco-Merth BD, Brantley W, Marenco A, Duell DD, Fachko DN, Richardson B, Busman-Sahay K, Shao D, Flores W, Engelman K, Fukazawa Y, Wong SW, Skalsky RL, Smedley J, Axthelm MK, Lifson JD, Estes JD, Edlefsen PT, Picker LJ, Cameron CM, Henrich TJ, Okoye AA. Varco-Merth BD, et al. J Clin Invest. 2022 May 16;132(10):e156063. doi: 10.1172/JCI156063. J Clin Invest. 2022. PMID: 35316218 Free PMC article.
Optimization and use of near infrared imaging to guide lymph node collection in rhesus macaques (Macaca mulatta).
Smedley JV, Bochart RM, Fischer M, Funderburgh H, Kelly V, Crank H, Armantrout K, Shiel O, Robertson-LeVay M, Sternberger N, Schmaling B, Roberts S, Sekiguchi V, Reusz M, Schwartz T, Meyer KA, Webb G, Gilbride RM, Dambrauskas N, Andrade D, Wood M, Labriola C, Axthelm M, Derby N, Varco-Merth B, Fukazawa Y, Hansen S, Sacha JB, Sodora DL, Sather DN. Smedley JV, et al. Among authors: varco merth b. J Med Primatol. 2022 Oct;51(5):270-277. doi: 10.1111/jmp.12605. Epub 2022 Jul 15. J Med Primatol. 2022. PMID: 35841132 Free PMC article.
Anti-PD-1 chimeric antigen receptor T cells efficiently target SIV-infected CD4+ T cells in germinal centers.
Eichholz K, Fukazawa Y, Peterson CW, Haeseleer F, Medina M, Hoffmeister S, Duell DM, Varco-Merth BD, Dross S, Park H, Labriola CS, Axthelm MK, Murnane RD, Smedley JV, Jin L, Gong J, Rust BJ, Fuller DH, Kiem HP, Picker LJ, Okoye AA, Corey L. Eichholz K, et al. Among authors: varco merth bd. J Clin Invest. 2024 Apr 1;134(7):e169309. doi: 10.1172/JCI169309. J Clin Invest. 2024. PMID: 38557496 Free PMC article.
Early antiretroviral therapy in SIV-infected rhesus macaques reveals a multiphasic, saturable dynamic accumulation of the rebound competent viral reservoir.
Keele BF, Okoye AA, Fennessey CM, Varco-Merth B, Immonen TT, Kose E, Conchas A, Pinkevych M, Lipkey L, Newman L, Macairan A, Bosche M, Bosche WJ, Berkemeier B, Fast R, Hull M, Oswald K, Shoemaker R, Silipino L, Gorelick RJ, Duell D, Marenco A, Brantley W, Smedley J, Axthelm M, Davenport MP, Lifson JD, Picker LJ. Keele BF, et al. Among authors: varco merth b. PLoS Pathog. 2024 Apr 9;20(4):e1012135. doi: 10.1371/journal.ppat.1012135. eCollection 2024 Apr. PLoS Pathog. 2024. PMID: 38593120 Free PMC article.
14 results