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Caloric restriction leads to druggable LSD1-dependent cancer stem cells expansion.
Pallavi R, Gatti E, Durfort T, Stendardo M, Ravasio R, Leonardi T, Falvo P, Duso BA, Punzi S, Xieraili A, Polazzi A, Verrelli D, Trastulli D, Ronzoni S, Frascolla S, Perticari G, Elgendy M, Varasi M, Colombo E, Giorgio M, Lanfrancone L, Minucci S, Mazzarella L, Pelicci PG. Pallavi R, et al. Among authors: varasi m. Nat Commun. 2024 Jan 27;15(1):828. doi: 10.1038/s41467-023-44348-y. Nat Commun. 2024. PMID: 38280853 Free PMC article.
GTF2I dosage regulates neuronal differentiation and social behavior in 7q11.23 neurodevelopmental disorders.
López-Tobón A, Shyti R, Villa CE, Cheroni C, Fuentes-Bravo P, Trattaro S, Caporale N, Troglio F, Tenderini E, Mihailovich M, Skaros A, Gibson WT, Cuomo A, Bonaldi T, Mercurio C, Varasi M, Osborne L, Testa G. López-Tobón A, et al. Among authors: varasi m. Sci Adv. 2023 Dec;9(48):eadh2726. doi: 10.1126/sciadv.adh2726. Epub 2023 Nov 29. Sci Adv. 2023. PMID: 38019906 Free PMC article.
Enrichment of DNA replication intermediates by EdU pull down.
Pessina F, Romussi A, Piccini D, Mazzucco G, Varasi M, Doksani Y. Pessina F, et al. Among authors: varasi m. Methods Cell Biol. 2024;182:83-94. doi: 10.1016/bs.mcb.2022.11.001. Epub 2022 Dec 13. Methods Cell Biol. 2024. PMID: 38359989
Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells.
Di Bello E, Sian V, Bontempi G, Zwergel C, Fioravanti R, Noce B, Castiello C, Tomassi S, Corinti D, Passeri D, Pellicciari R, Mercurio C, Varasi M, Altucci L, Tripodi M, Strippoli R, Nebbioso A, Valente S, Mai A. Di Bello E, et al. Among authors: varasi m. Eur J Med Chem. 2023 Feb 5;247:115022. doi: 10.1016/j.ejmech.2022.115022. Epub 2022 Dec 15. Eur J Med Chem. 2023. PMID: 36549114
LSD1-directed therapy affects glioblastoma tumorigenicity by deregulating the protective ATF4-dependent integrated stress response.
Faletti S, Osti D, Ceccacci E, Richichi C, Costanza B, Nicosia L, Noberini R, Marotta G, Furia L, Faretta MR, Brambillasca S, Quarto M, Bertero L, Boldorini R, Pollo B, Gandini S, Cora D, Minucci S, Mercurio C, Varasi M, Bonaldi T, Pelicci G. Faletti S, et al. Among authors: varasi m. Sci Transl Med. 2021 Dec 8;13(623):eabf7036. doi: 10.1126/scitranslmed.abf7036. Epub 2021 Dec 8. Sci Transl Med. 2021. PMID: 34878824
High-throughput screening identifies histone deacetylase inhibitors that modulate GTF2I expression in 7q11.23 microduplication autism spectrum disorder patient-derived cortical neurons.
Cavallo F, Troglio F, Fagà G, Fancelli D, Shyti R, Trattaro S, Zanella M, D'Agostino G, Hughes JM, Cera MR, Pasi M, Gabriele M, Lazzarin M, Mihailovich M, Kooy F, Rosa A, Mercurio C, Varasi M, Testa G. Cavallo F, et al. Among authors: varasi m. Mol Autism. 2020 Nov 19;11(1):88. doi: 10.1186/s13229-020-00387-6. Mol Autism. 2020. PMID: 33208191 Free PMC article.
Discovery of Reversible Inhibitors of KDM1A Efficacious in Acute Myeloid Leukemia Models.
Romussi A, Cappa A, Vianello P, Brambillasca S, Cera MR, Dal Zuffo R, Fagà G, Fattori R, Moretti L, Trifirò P, Villa M, Vultaggio S, Cecatiello V, Pasqualato S, Dondio G, So CWE, Minucci S, Sartori L, Varasi M, Mercurio C. Romussi A, et al. Among authors: varasi m. ACS Med Chem Lett. 2020 Feb 13;11(5):754-759. doi: 10.1021/acsmedchemlett.9b00604. eCollection 2020 May 14. ACS Med Chem Lett. 2020. PMID: 32435381 Free PMC article.
Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid-induced differentiation.
Ravasio R, Ceccacci E, Nicosia L, Hosseini A, Rossi PL, Barozzi I, Fornasari L, Zuffo RD, Valente S, Fioravanti R, Mercurio C, Varasi M, Mattevi A, Mai A, Pavesi G, Bonaldi T, Minucci S. Ravasio R, et al. Among authors: varasi m. Sci Adv. 2020 Apr 8;6(15):eaax2746. doi: 10.1126/sciadv.aax2746. eCollection 2020 Apr. Sci Adv. 2020. PMID: 32284990 Free PMC article.
Tranylcypromine-Based LSD1 Inhibitors: Structure-Activity Relationships, Antiproliferative Effects in Leukemia, and Gene Target Modulation.
Fioravanti R, Romanelli A, Mautone N, Di Bello E, Rovere A, Corinti D, Zwergel C, Valente S, Rotili D, Botrugno OA, Dessanti P, Vultaggio S, Vianello P, Cappa A, Binda C, Mattevi A, Minucci S, Mercurio C, Varasi M, Mai A. Fioravanti R, et al. Among authors: varasi m. ChemMedChem. 2020 Apr 3;15(7):643-658. doi: 10.1002/cmdc.201900730. Epub 2020 Feb 14. ChemMedChem. 2020. PMID: 32003940 Free PMC article.
78 results