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Immunogenicity and Protective Efficacy of a Highly Thermotolerant, Trimeric SARS-CoV-2 Receptor Binding Domain Derivative.
Malladi SK, Patel UR, Rajmani RS, Singh R, Pandey S, Kumar S, Khaleeq S, van Vuren PJ, Riddell S, Goldie S, Gayathri S, Chakraborty D, Kalita P, Pramanick I, Agarwal N, Reddy P, Girish N, Upadhyaya A, Khan MS, Kanjo K, Bhat M, Mani S, Bhattacharyya S, Siddiqui S, Tyagi A, Jha S, Pandey R, Tripathi S, Dutta S, McAuley AJ, Singanallur NB, Vasan SS, Ringe RP, Varadarajan R. Malladi SK, et al. Among authors: varadarajan r. ACS Infect Dis. 2021 Aug 13;7(8):2546-2564. doi: 10.1021/acsinfecdis.1c00276. Epub 2021 Jul 14. ACS Infect Dis. 2021. PMID: 34260218 Free PMC article.
A Stabilized, Monomeric, Receptor Binding Domain Elicits High-Titer Neutralizing Antibodies Against All SARS-CoV-2 Variants of Concern.
Ahmed S, Khan MS, Gayathri S, Singh R, Kumar S, Patel UR, Malladi SK, Rajmani RS, van Vuren PJ, Riddell S, Goldie S, Girish N, Reddy P, Upadhyaya A, Pandey S, Siddiqui S, Tyagi A, Jha S, Pandey R, Khatun O, Narayan R, Tripathi S, McAuley AJ, Singanallur NB, Vasan SS, Ringe RP, Varadarajan R. Ahmed S, et al. Among authors: varadarajan r. Front Immunol. 2021 Dec 9;12:765211. doi: 10.3389/fimmu.2021.765211. eCollection 2021. Front Immunol. 2021. PMID: 34956193 Free PMC article.
A dimeric proteomimetic prevents SARS-CoV-2 infection by dimerizing the spike protein.
Khatri B, Pramanick I, Malladi SK, Rajmani RS, Kumar S, Ghosh P, Sengupta N, Rahisuddin R, Kumar N, Kumaran S, Ringe RP, Varadarajan R, Dutta S, Chatterjee J. Khatri B, et al. Among authors: varadarajan r. Nat Chem Biol. 2022 Oct;18(10):1046-1055. doi: 10.1038/s41589-022-01060-0. Epub 2022 Jun 2. Nat Chem Biol. 2022. PMID: 35654847 Free PMC article.
Mechanistic insights into global suppressors of protein folding defects.
Chattopadhyay G, Bhowmick J, Manjunath K, Ahmed S, Goyal P, Varadarajan R. Chattopadhyay G, et al. Among authors: varadarajan r. PLoS Genet. 2022 Aug 29;18(8):e1010334. doi: 10.1371/journal.pgen.1010334. eCollection 2022 Aug. PLoS Genet. 2022. PMID: 36037221 Free PMC article.
Identification of diphenylurea derivatives as novel endocytosis inhibitors that demonstrate broad-spectrum activity against SARS-CoV-2 and influenza A virus both in vitro and in vivo.
Kumar N, Taily IM, Singh C, Kumar S, Rajmani RS, Chakraborty D, Sharma A, Singh P, Thakur KG, Varadarajan R, Ringe RP, Banerjee P, Banerjee I. Kumar N, et al. Among authors: varadarajan r. PLoS Pathog. 2023 May 1;19(5):e1011358. doi: 10.1371/journal.ppat.1011358. eCollection 2023 May. PLoS Pathog. 2023. PMID: 37126530 Free PMC article.
209 results