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Nanobody engineering for SARS-CoV-2 neutralization and detection.
Hannula L, Kuivanen S, Lasham J, Kant R, Kareinen L, Bogacheva M, Strandin T, Sironen T, Hepojoki J, Sharma V, Saviranta P, Kipar A, Vapalahti O, Huiskonen JT, Rissanen I. Hannula L, et al. Among authors: vapalahti o. Microbiol Spectr. 2024 Apr 2;12(4):e0419922. doi: 10.1128/spectrum.04199-22. Epub 2024 Feb 16. Microbiol Spectr. 2024. PMID: 38363137 Free PMC article.
Complete Protection from SARS-CoV-2 Lung Infection in Mice Through Combined Intranasal Delivery of PIKfyve Kinase and TMPRSS2 Protease Inhibitors.
Kant R, Kareinen L, Ojha R, Strandin T, Saber SH, Lesnikova A, Kuivanen S, Sirnonen T, Joensuu M, Vapalahti O, Kirchhausen T, Kipar A, Balistreri G. Kant R, et al. Among authors: vapalahti o. bioRxiv [Preprint]. 2023 Jul 20:2023.07.19.549731. doi: 10.1101/2023.07.19.549731. bioRxiv. 2023. PMID: 37503261 Free PMC article. Preprint.
Mucosal-Associated Invariant T Cells are not susceptible in vitro to SARS-CoV-2 infection but accumulate into the lungs of COVID-19 patients.
Huang X, Kantonen J, Nowlan K, Nguyen NA, Jokiranta ST, Kuivanen S, Heikkilä N, Mahzabin S, Kantele A, Vapalahti O, Myllykangas L, Heinonen S, Mäyränpää MI, Strandin T, Kekäläinen E. Huang X, et al. Among authors: vapalahti o. Virus Res. 2024 Mar;341:199315. doi: 10.1016/j.virusres.2024.199315. Epub 2024 Jan 13. Virus Res. 2024. PMID: 38211733 Free PMC article.
Drug repurposing platform for deciphering the druggable SARS-CoV-2 interactome.
Bogacheva MS, Kuivanen S, Potdar S, Hassinen A, Huuskonen S, Pöhner I, Luck TJ, Turunen L, Feodoroff M, Szirovicza L, Savijoki K, Saarela J, Tammela P, Paavolainen L, Poso A, Varjosalo M, Kallioniemi O, Pietiäinen V, Vapalahti O. Bogacheva MS, et al. Among authors: vapalahti o. Antiviral Res. 2024 Mar;223:105813. doi: 10.1016/j.antiviral.2024.105813. Epub 2024 Jan 24. Antiviral Res. 2024. PMID: 38272320 Free article.
Exposure to urban particulate matter alters responses of olfactory mucosal cells to SARS-CoV-2 infection.
Shahbaz MA, Kuivanen S, Mussalo L, Afonin AM, Kumari K, Behzadpour D, Kalapudas J, Koivisto AM, Penttilä E, Löppönen H, Jalava P, Vapalahti O, Balistreri G, Lampinen R, Kanninen KM. Shahbaz MA, et al. Among authors: vapalahti o. Environ Res. 2024 May 15;249:118451. doi: 10.1016/j.envres.2024.118451. Epub 2024 Feb 8. Environ Res. 2024. PMID: 38341073 Free article.
Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the pre-hairpin intermediate of the spike protein.
Yang K, Wang C, Kreutzberger AJB, Ojha R, Kuivanen S, Couoh-Cardel S, Muratcioglu S, Eisen TJ, White KI, Held RG, Subramanian S, Marcus K, Pfuetzner RA, Esquivies L, Doyle CA, Kuriyan J, Vapalahti O, Balistreri G, Kirchhausen T, Brunger AT. Yang K, et al. Among authors: vapalahti o. bioRxiv [Preprint]. 2022 Aug 11:2022.08.11.503553. doi: 10.1101/2022.08.11.503553. bioRxiv. 2022. PMID: 35982670 Free PMC article. Updated. Preprint.
The α-dystroglycan N-terminus is a broad-spectrum antiviral agent against SARS-CoV-2 and enveloped viruses.
Bigotti MG, Klein K, Gan ES, Anastasina M, Andersson S, Vapalahti O, Katajisto P, Erdmann M, Davidson AD, Butcher SJ, Collinson I, Ooi EE, Balistreri G, Brancaccio A, Yamauchi Y. Bigotti MG, et al. Among authors: vapalahti o. Antiviral Res. 2024 Apr;224:105837. doi: 10.1016/j.antiviral.2024.105837. Epub 2024 Feb 20. Antiviral Res. 2024. PMID: 38387750 Free article.
Addressing pandemic-wide systematic errors in the SARS-CoV-2 phylogeny.
Hunt M, Hinrichs AS, Anderson D, Karim L, Dearlove BL, Knaggs J, Constantinides B, Fowler PW, Rodger G, Street T, Lumley S, Webster H, Sanderson T, Ruis C, de Maio N, Amenga-Etego LN, Amuzu DSY, Avaro M, Awandare GA, Ayivor-Djanie R, Bashton M, Batty EM, Bediako Y, Belder D, Benedetti E, Bergthaler A, Boers SA, Campos J, Ampomah Carr RA, Cuba F, Dattero ME, Dejnirattisai W, Dilthey A, Duedu KO, Endler L, Engelmann I, Francisco NM, Fuchs J, Gnimpieba EZ, Groc S, Gyamfi J, Heemskerk D, Houwaart T, Hsiao NY, Huska M, Hölzer M, Iranzadeh A, Jarva H, Jeewandara C, Jolly B, Joseph R, Kant R, Ki KKK, Kurkela S, Lappalainen M, Lataretu M, Liu C, Malavige GN, Mashe T, Mongkolsapaya J, Montes B, Molina Mora JA, Morang'a CM, Mvula B, Nagarajan N, Nelson A, Ngoi JM, da Paixão JP, Panning M, Poklepovich T, Quashie PK, Ranasinghe D, Russo M, San JE, Sanderson ND, Scaria V, Screaton G, Sironen T, Sisay A, Smith D, Smura T, Supasa P, Suphavilai C, Swann J, Tegally H, Tegomoh B, Vapalahti O, Walker A, Wilkinson RJ, Williamson C; IMSSC2 Laboratory Network Consortium; de Oliveira T, Peto TE, Crook D, Corbett-Detig R, Iqbal Z. Hunt M, et al. Among authors: vapalahti o. bioRxiv [Preprint]. 2024 Apr 30:2024.04.29.591666. doi: 10.1101/2024.04.29.591666. bioRxiv. 2024. PMID: 38746185 Free PMC article. Preprint.
439 results