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A small-molecule PI3Kα activator for cardioprotection and neuroregeneration.
Gong GQ, Bilanges B, Allsop B, Masson GR, Roberton V, Askwith T, Oxenford S, Madsen RR, Conduit SE, Bellini D, Fitzek M, Collier M, Najam O, He Z, Wahab B, McLaughlin SH, Chan AWE, Feierberg I, Madin A, Morelli D, Bhamra A, Vinciauskaite V, Anderson KE, Surinova S, Pinotsis N, Lopez-Guadamillas E, Wilcox M, Hooper A, Patel C, Whitehead MA, Bunney TD, Stephens LR, Hawkins PT, Katan M, Yellon DM, Davidson SM, Smith DM, Phillips JB, Angell R, Williams RL, Vanhaesebroeck B. Gong GQ, et al. Among authors: vanhaesebroeck b. Nature. 2023 Jun;618(7963):159-168. doi: 10.1038/s41586-023-05972-2. Epub 2023 May 24. Nature. 2023. PMID: 37225977 Free PMC article.
Phosphatidylinositol-3-OH kinase as a direct target of Ras.
Rodriguez-Viciana P, Warne PH, Dhand R, Vanhaesebroeck B, Gout I, Fry MJ, Waterfield MD, Downward J. Rodriguez-Viciana P, et al. Among authors: vanhaesebroeck b. Nature. 1994 Aug 18;370(6490):527-32. doi: 10.1038/370527a0. Nature. 1994. PMID: 8052307
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils.
Condliffe AM, Davidson K, Anderson KE, Ellson CD, Crabbe T, Okkenhaug K, Vanhaesebroeck B, Turner M, Webb L, Wymann MP, Hirsch E, Ruckle T, Camps M, Rommel C, Jackson SP, Chilvers ER, Stephens LR, Hawkins PT. Condliffe AM, et al. Among authors: vanhaesebroeck b. Blood. 2005 Aug 15;106(4):1432-40. doi: 10.1182/blood-2005-03-0944. Epub 2005 May 5. Blood. 2005. PMID: 15878979 Free article.
Killing two kinase families with one stone.
Bilanges B, Torbett N, Vanhaesebroeck B. Bilanges B, et al. Among authors: vanhaesebroeck b. Nat Chem Biol. 2008 Nov;4(11):648-9. doi: 10.1038/nchembio1108-648. Nat Chem Biol. 2008. PMID: 18936744 No abstract available.
The emerging mechanisms of isoform-specific PI3K signalling.
Vanhaesebroeck B, Guillermet-Guibert J, Graupera M, Bilanges B. Vanhaesebroeck B, et al. Nat Rev Mol Cell Biol. 2010 May;11(5):329-41. doi: 10.1038/nrm2882. Epub 2010 Apr 9. Nat Rev Mol Cell Biol. 2010. PMID: 20379207 Review.
A new tool to dissect the function of p70 S6 kinase.
Bilanges B, Vanhaesebroeck B. Bilanges B, et al. Among authors: vanhaesebroeck b. Biochem J. 2010 Oct 15;431(2):e1-3. doi: 10.1042/BJ20101445. Biochem J. 2010. PMID: 20874709
PI3Kβ plays a critical role in neutrophil activation by immune complexes.
Kulkarni S, Sitaru C, Jakus Z, Anderson KE, Damoulakis G, Davidson K, Hirose M, Juss J, Oxley D, Chessa TA, Ramadani F, Guillou H, Segonds-Pichon A, Fritsch A, Jarvis GE, Okkenhaug K, Ludwig R, Zillikens D, Mocsai A, Vanhaesebroeck B, Stephens LR, Hawkins PT. Kulkarni S, et al. Among authors: vanhaesebroeck b. Sci Signal. 2011 Apr 12;4(168):ra23. doi: 10.1126/scisignal.2001617. Sci Signal. 2011. PMID: 21487106
216 results