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mTORC1 activity is supported by spatial association with focal adhesions.
Rabanal-Ruiz Y, Byron A, Wirth A, Madsen R, Sedlackova L, Hewitt G, Nelson G, Stingele J, Wills JC, Zhang T, Zeug A, Fässler R, Vanhaesebroeck B, Maddocks ODK, Ponimaskin E, Carroll B, Korolchuk VI. Rabanal-Ruiz Y, et al. Among authors: vanhaesebroeck b. J Cell Biol. 2021 May 3;220(5):e202004010. doi: 10.1083/jcb.202004010. J Cell Biol. 2021. PMID: 33635313 Free PMC article.
Cancer-Associated PIK3CA Mutations in Overgrowth Disorders.
Madsen RR, Vanhaesebroeck B, Semple RK. Madsen RR, et al. Among authors: vanhaesebroeck b. Trends Mol Med. 2018 Oct;24(10):856-870. doi: 10.1016/j.molmed.2018.08.003. Epub 2018 Sep 6. Trends Mol Med. 2018. PMID: 30197175 Free PMC article. Review.
Oncogenic PIK3CA promotes cellular stemness in an allele dose-dependent manner.
Madsen RR, Knox RG, Pearce W, Lopez S, Mahler-Araujo B, McGranahan N, Vanhaesebroeck B, Semple RK. Madsen RR, et al. Among authors: vanhaesebroeck b. Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8380-8389. doi: 10.1073/pnas.1821093116. Epub 2019 Apr 4. Proc Natl Acad Sci U S A. 2019. PMID: 30948643 Free PMC article.
Cracking the context-specific PI3K signaling code.
Madsen RR, Vanhaesebroeck B. Madsen RR, et al. Among authors: vanhaesebroeck b. Sci Signal. 2020 Jan 7;13(613):eaay2940. doi: 10.1126/scisignal.aay2940. Sci Signal. 2020. PMID: 31911433 Review.
Gene targeting: attention to detail.
Vanhaesebroeck B, Rohn JL, Waterfield MD. Vanhaesebroeck B, et al. Cell. 2004 Aug 6;118(3):274-6. doi: 10.1016/j.cell.2004.07.018. Cell. 2004. PMID: 15294152 Free article.
218 results