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Essential role for the p110delta isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia.
Sujobert P, Bardet V, Cornillet-Lefebvre P, Hayflick JS, Prie N, Verdier F, Vanhaesebroeck B, Muller O, Pesce F, Ifrah N, Hunault-Berger M, Berthou C, Villemagne B, Jourdan E, Audhuy B, Solary E, Witz B, Harousseau JL, Himberlin C, Lamy T, Lioure B, Cahn JY, Dreyfus F, Mayeux P, Lacombe C, Bouscary D. Sujobert P, et al. Among authors: vanhaesebroeck b. Blood. 2005 Aug 1;106(3):1063-6. doi: 10.1182/blood-2004-08-3225. Epub 2005 Apr 19. Blood. 2005. PMID: 15840695 Free article.
Deletion of the p110beta isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo.
Martin V, Guillermet-Guibert J, Chicanne G, Cabou C, Jandrot-Perrus M, Plantavid M, Vanhaesebroeck B, Payrastre B, Gratacap MP. Martin V, et al. Among authors: vanhaesebroeck b. Blood. 2010 Mar 11;115(10):2008-13. doi: 10.1182/blood-2009-04-217224. Epub 2010 Jan 11. Blood. 2010. PMID: 20065293 Free article.
PI3Kα is essential for the recovery from Cre/tamoxifen cardiotoxicity and in myocardial insulin signalling but is not required for normal myocardial contractility in the adult heart.
McLean BA, Zhabyeyev P, Patel VB, Basu R, Parajuli N, DesAulniers J, Murray AG, Kassiri Z, Vanhaesebroeck B, Oudit GY. McLean BA, et al. Among authors: vanhaesebroeck b. Cardiovasc Res. 2015 Mar 1;105(3):292-303. doi: 10.1093/cvr/cvv016. Epub 2015 Jan 24. Cardiovasc Res. 2015. PMID: 25618408
Essential role of class II PI3K-C2α in platelet membrane morphology.
Valet C, Chicanne G, Severac C, Chaussade C, Whitehead MA, Cabou C, Gratacap MP, Gaits-Iacovoni F, Vanhaesebroeck B, Payrastre B, Severin S. Valet C, et al. Among authors: vanhaesebroeck b. Blood. 2015 Aug 27;126(9):1128-37. doi: 10.1182/blood-2015-03-636670. Epub 2015 Jun 24. Blood. 2015. PMID: 26109204 Free article.
A dual role for the class III PI3K, Vps34, in platelet production and thrombus growth.
Valet C, Levade M, Chicanne G, Bilanges B, Cabou C, Viaud J, Gratacap MP, Gaits-Iacovoni F, Vanhaesebroeck B, Payrastre B, Severin S. Valet C, et al. Among authors: vanhaesebroeck b. Blood. 2017 Nov 2;130(18):2032-2042. doi: 10.1182/blood-2017-04-781641. Epub 2017 Sep 13. Blood. 2017. PMID: 28903944 Free PMC article.
Impact of PI3Kα (Phosphoinositide 3-Kinase Alpha) Inhibition on Hemostasis and Thrombosis.
Laurent PA, Hechler B, Solinhac R, Ragab A, Cabou C, Anquetil T, Severin S, Denis CV, Mangin PH, Vanhaesebroeck B, Payrastre B, Gratacap MP. Laurent PA, et al. Among authors: vanhaesebroeck b. Arterioscler Thromb Vasc Biol. 2018 Sep;38(9):2041-2053. doi: 10.1161/ATVBAHA.118.311410. Arterioscler Thromb Vasc Biol. 2018. PMID: 30354258
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