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238 results

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Page 1
Histone Deacetylase 6 Inhibition Exploits Selective Metabolic Vulnerabilities in LKB1 Mutant, KRAS Driven NSCLC.
Zhang H, Nabel CS, Li D, O'Connor RÍ, Crosby CR, Chang SM, Hao Y, Stanley R, Sahu S, Levin DS, Chen T, Tang S, Huang HY, Meynardie M, Stephens J, Sherman F, Chafitz A, Costelloe N, Rodrigues DA, Fogarty H, Kiernan MG, Cronin F, Papadopoulos E, Ploszaj M, Weerasekara V, Deng J, Kiely P, Bardeesy N, Vander Heiden MG, Chonghaile TN, Dowling CM, Wong KK. Zhang H, et al. Among authors: vander heiden mg. J Thorac Oncol. 2023 Jul;18(7):882-895. doi: 10.1016/j.jtho.2023.03.014. Epub 2023 Mar 22. J Thorac Oncol. 2023. PMID: 36958689 Free article.
Identification of DHODH as a therapeutic target in small cell lung cancer.
Li L, Ng SR, Colón CI, Drapkin BJ, Hsu PP, Li Z, Nabel CS, Lewis CA, Romero R, Mercer KL, Bhutkar A, Phat S, Myers DT, Muzumdar MD, Westcott PMK, Beytagh MC, Farago AF, Vander Heiden MG, Dyson NJ, Jacks T. Li L, et al. Among authors: vander heiden mg. Sci Transl Med. 2019 Nov 6;11(517):eaaw7852. doi: 10.1126/scitranslmed.aaw7852. Sci Transl Med. 2019. PMID: 31694929 Free PMC article.
Inhibiting GLUTtony in cancer.
Chang SM, Vander Heiden MG. Chang SM, et al. Among authors: vander heiden mg. Cell Chem Biol. 2022 Mar 17;29(3):353-355. doi: 10.1016/j.chembiol.2022.03.004. Cell Chem Biol. 2022. PMID: 35303439 Free article.
Nucleotide imbalance decouples cell growth from cell proliferation.
Diehl FF, Miettinen TP, Elbashir R, Nabel CS, Darnell AM, Do BT, Manalis SR, Lewis CA, Vander Heiden MG. Diehl FF, et al. Among authors: vander heiden mg. Nat Cell Biol. 2022 Aug;24(8):1252-1264. doi: 10.1038/s41556-022-00965-1. Epub 2022 Aug 4. Nat Cell Biol. 2022. PMID: 35927450 Free PMC article.
Unprocessed genomic uracil as a source of DNA replication stress in cancer cells.
Saxena S, Nabel CS, Seay TW, Patel PS, Kawale AS, Crosby CR, Tigro H, Oh E, Vander Heiden MG, Hata AN, Suo Z, Zou L. Saxena S, et al. Among authors: vander heiden mg. Mol Cell. 2024 Apr 22:S1097-2765(24)00282-X. doi: 10.1016/j.molcel.2024.04.004. Online ahead of print. Mol Cell. 2024. PMID: 38688279
Development of a colon cancer GEMM-derived orthotopic transplant model for drug discovery and validation.
Martin ES, Belmont PJ, Sinnamon MJ, Richard LG, Yuan J, Coffee EM, Roper J, Lee L, Heidari P, Lunt SY, Goel G, Ji X, Xie Z, Xie T, Lamb J, Weinrich SL, VanArsdale T, Bronson RT, Xavier RJ, Vander Heiden MG, Kan JL, Mahmood U, Hung KE. Martin ES, et al. Among authors: vander heiden mg. Clin Cancer Res. 2013 Jun 1;19(11):2929-40. doi: 10.1158/1078-0432.CCR-12-2307. Epub 2013 Feb 12. Clin Cancer Res. 2013. PMID: 23403635 Free PMC article.
Targetable signaling pathway mutations are associated with malignant phenotype in IDH-mutant gliomas.
Wakimoto H, Tanaka S, Curry WT, Loebel F, Zhao D, Tateishi K, Chen J, Klofas LK, Lelic N, Kim JC, Dias-Santagata D, Ellisen LW, Borger DR, Fendt SM, Vander Heiden MG, Batchelor TT, Iafrate AJ, Cahill DP, Chi AS. Wakimoto H, et al. Among authors: vander heiden mg. Clin Cancer Res. 2014 Jun 1;20(11):2898-909. doi: 10.1158/1078-0432.CCR-13-3052. Epub 2014 Apr 8. Clin Cancer Res. 2014. PMID: 24714777 Free PMC article.
Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer.
Davidson SM, Papagiannakopoulos T, Olenchock BA, Heyman JE, Keibler MA, Luengo A, Bauer MR, Jha AK, O'Brien JP, Pierce KA, Gui DY, Sullivan LB, Wasylenko TM, Subbaraj L, Chin CR, Stephanopolous G, Mott BT, Jacks T, Clish CB, Vander Heiden MG. Davidson SM, et al. Among authors: vander heiden mg. Cell Metab. 2016 Mar 8;23(3):517-28. doi: 10.1016/j.cmet.2016.01.007. Epub 2016 Feb 4. Cell Metab. 2016. PMID: 26853747 Free PMC article.
Metabolic requirements for cancer cell proliferation.
Keibler MA, Wasylenko TM, Kelleher JK, Iliopoulos O, Vander Heiden MG, Stephanopoulos G. Keibler MA, et al. Among authors: vander heiden mg. Cancer Metab. 2016 Aug 18;4:16. doi: 10.1186/s40170-016-0156-6. eCollection 2016. Cancer Metab. 2016. PMID: 27540483 Free PMC article.
238 results