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Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition.
Ngo B, Kim E, Osorio-Vasquez V, Doll S, Bustraan S, Liang RJ, Luengo A, Davidson SM, Ali A, Ferraro GB, Fischer GM, Eskandari R, Kang DS, Ni J, Plasger A, Rajasekhar VK, Kastenhuber ER, Bacha S, Sriram RK, Stein BD, Bakhoum SF, Snuderl M, Cotzia P, Healey JH, Mainolfi N, Suri V, Friedman A, Manfredi M, Sabatini DM, Jones DR, Yu M, Zhao JJ, Jain RK, Keshari KR, Davies MA, Vander Heiden MG, Hernando E, Mann M, Cantley LC, Pacold ME. Ngo B, et al. Among authors: vander heiden mg. Cancer Discov. 2020 Sep;10(9):1352-1373. doi: 10.1158/2159-8290.CD-19-1228. Epub 2020 Jun 22. Cancer Discov. 2020. PMID: 32571778 Free PMC article.
Pyruvate kinase M2 is a phosphotyrosine-binding protein.
Christofk HR, Vander Heiden MG, Wu N, Asara JM, Cantley LC. Christofk HR, et al. Among authors: vander heiden mg. Nature. 2008 Mar 13;452(7184):181-6. doi: 10.1038/nature06667. Nature. 2008. PMID: 18337815
Cancer's insatiable appetite.
Locasale JW, Cantley LC, Vander Heiden MG. Locasale JW, et al. Among authors: vander heiden mg. Nat Biotechnol. 2009 Oct;27(10):916-7. doi: 10.1038/nbt1009-916. Nat Biotechnol. 2009. PMID: 19816448 Free PMC article.
Identification of small molecule inhibitors of pyruvate kinase M2.
Vander Heiden MG, Christofk HR, Schuman E, Subtelny AO, Sharfi H, Harlow EE, Xian J, Cantley LC. Vander Heiden MG, et al. Biochem Pharmacol. 2010 Apr 15;79(8):1118-24. doi: 10.1016/j.bcp.2009.12.003. Epub 2009 Dec 11. Biochem Pharmacol. 2010. PMID: 20005212 Free PMC article.
Evidence for an alternative glycolytic pathway in rapidly proliferating cells.
Vander Heiden MG, Locasale JW, Swanson KD, Sharfi H, Heffron GJ, Amador-Noguez D, Christofk HR, Wagner G, Rabinowitz JD, Asara JM, Cantley LC. Vander Heiden MG, et al. Science. 2010 Sep 17;329(5998):1492-9. doi: 10.1126/science.1188015. Science. 2010. PMID: 20847263 Free PMC article.
Rewiring of glycolysis in cancer cell metabolism.
Locasale JW, Vander Heiden MG, Cantley LC. Locasale JW, et al. Among authors: vander heiden mg. Cell Cycle. 2010 Nov 1;9(21):4253. doi: 10.4161/cc.9.21.13925. Epub 2010 Nov 7. Cell Cycle. 2010. PMID: 21045562 No abstract available.
238 results