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Glycogen synthase kinase 3 is a potential drug target for African trypanosomiasis therapy.
Ojo KK, Gillespie JR, Riechers AJ, Napuli AJ, Verlinde CL, Buckner FS, Gelb MH, Domostoj MM, Wells SJ, Scheer A, Wells TN, Van Voorhis WC. Ojo KK, et al. Among authors: van voorhis wc. Antimicrob Agents Chemother. 2008 Oct;52(10):3710-7. doi: 10.1128/AAC.00364-08. Epub 2008 Jul 21. Antimicrob Agents Chemother. 2008. PMID: 18644955 Free PMC article.
Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors.
Ojo KK, Larson ET, Keyloun KR, Castaneda LJ, Derocher AE, Inampudi KK, Kim JE, Arakaki TL, Murphy RC, Zhang L, Napuli AJ, Maly DJ, Verlinde CL, Buckner FS, Parsons M, Hol WG, Merritt EA, Van Voorhis WC. Ojo KK, et al. Among authors: van voorhis wc. Nat Struct Mol Biol. 2010 May;17(5):602-7. doi: 10.1038/nsmb.1818. Epub 2010 May 2. Nat Struct Mol Biol. 2010. PMID: 20436472 Free PMC article.
Discovery of Potent and Selective Inhibitors of Calcium-Dependent Protein Kinase 1 (CDPK1) from C. parvum and T. gondii.
Murphy RC, Ojo KK, Larson ET, Castellanos-Gonzalez A, Perera BG, Keyloun KR, Kim JE, Bhandari JG, Muller NR, Verlinde CL, White AC Jr, Merritt EA, Van Voorhis WC, Maly DJ. Murphy RC, et al. Among authors: van voorhis wc. ACS Med Chem Lett. 2010 Oct 14;1(7):331-335. doi: 10.1021/ml100096t. ACS Med Chem Lett. 2010. PMID: 21116453 Free PMC article.
Structure determination of glycogen synthase kinase-3 from Leishmania major and comparative inhibitor structure-activity relationships with Trypanosoma brucei GSK-3.
Ojo KK, Arakaki TL, Napuli AJ, Inampudi KK, Keyloun KR, Zhang L, Hol WG, Verlinde CL, Merritt EA, Van Voorhis WC. Ojo KK, et al. Among authors: van voorhis wc. Mol Biochem Parasitol. 2011 Apr;176(2):98-108. doi: 10.1016/j.molbiopara.2010.12.009. Epub 2010 Dec 30. Mol Biochem Parasitol. 2011. PMID: 21195115 Free PMC article.
Development of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) inhibitors with potent anti-toxoplasma activity.
Johnson SM, Murphy RC, Geiger JA, DeRocher AE, Zhang Z, Ojo KK, Larson ET, Perera BG, Dale EJ, He P, Reid MC, Fox AM, Mueller NR, Merritt EA, Fan E, Parsons M, Van Voorhis WC, Maly DJ. Johnson SM, et al. Among authors: van voorhis wc. J Med Chem. 2012 Mar 8;55(5):2416-26. doi: 10.1021/jm201713h. Epub 2012 Feb 27. J Med Chem. 2012. PMID: 22320388 Free PMC article.
Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1.
Larson ET, Ojo KK, Murphy RC, Johnson SM, Zhang Z, Kim JE, Leibly DJ, Fox AM, Reid MC, Dale EJ, Perera BG, Kim J, Hewitt SN, Hol WG, Verlinde CL, Fan E, Van Voorhis WC, Maly DJ, Merritt EA. Larson ET, et al. Among authors: van voorhis wc. J Med Chem. 2012 Mar 22;55(6):2803-10. doi: 10.1021/jm201725v. Epub 2012 Mar 13. J Med Chem. 2012. PMID: 22369268 Free PMC article.
Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors.
Ojo KK, Pfander C, Mueller NR, Burstroem C, Larson ET, Bryan CM, Fox AM, Reid MC, Johnson SM, Murphy RC, Kennedy M, Mann H, Leibly DJ, Hewitt SN, Verlinde CL, Kappe S, Merritt EA, Maly DJ, Billker O, Van Voorhis WC. Ojo KK, et al. Among authors: van voorhis wc. J Clin Invest. 2012 Jun;122(6):2301-5. doi: 10.1172/JCI61822. Epub 2012 May 8. J Clin Invest. 2012. PMID: 22565309 Free PMC article.
Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1.
Zhang Z, Ojo KK, Johnson SM, Larson ET, He P, Geiger JA, Castellanos-Gonzalez A, White AC Jr, Parsons M, Merritt EA, Maly DJ, Verlinde CL, Van Voorhis WC, Fan E. Zhang Z, et al. Among authors: van voorhis wc. Bioorg Med Chem Lett. 2012 Aug 15;22(16):5264-7. doi: 10.1016/j.bmcl.2012.06.050. Epub 2012 Jun 23. Bioorg Med Chem Lett. 2012. PMID: 22795629 Free PMC article.
328 results