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Page 1
T-ALL can evolve to oncogene independence.
Abdulla H, Vo A, Shields BJ, Davies TJ, Jackson JT, Alserihi R, Viney EM, Wong T, Yan F, Wong NC, Demoen L, Curtis DJ, Alexander WS, Van Vlierberghe P, Dickins RA, McCormack MP. Abdulla H, et al. Among authors: van vlierberghe p. Leukemia. 2021 Aug;35(8):2205-2219. doi: 10.1038/s41375-021-01120-9. Epub 2021 Jan 22. Leukemia. 2021. PMID: 33483615
MicroRNA-193b-3p acts as a tumor suppressor by targeting the MYB oncogene in T-cell acute lymphoblastic leukemia.
Mets E, Van der Meulen J, Van Peer G, Boice M, Mestdagh P, Van de Walle I, Lammens T, Goossens S, De Moerloose B, Benoit Y, Van Roy N, Clappier E, Poppe B, Vandesompele J, Wendel HG, Taghon T, Rondou P, Soulier J, Van Vlierberghe P, Speleman F. Mets E, et al. Among authors: van der meulen j, van de walle i, van peer g, van roy n, van vlierberghe p. Leukemia. 2015 Apr;29(4):798-806. doi: 10.1038/leu.2014.276. Epub 2014 Sep 18. Leukemia. 2015. PMID: 25231743 Free PMC article.
ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling.
Goossens S, Radaelli E, Blanchet O, Durinck K, Van der Meulen J, Peirs S, Taghon T, Tremblay CS, Costa M, Farhang Ghahremani M, De Medts J, Bartunkova S, Haigh K, Schwab C, Farla N, Pieters T, Matthijssens F, Van Roy N, Best JA, Deswarte K, Bogaert P, Carmichael C, Rickard A, Suryani S, Bracken LS, Alserihi R, Canté-Barrett K, Haenebalcke L, Clappier E, Rondou P, Slowicka K, Huylebroeck D, Goldrath AW, Janzen V, McCormack MP, Lock RB, Curtis DJ, Harrison C, Berx G, Speleman F, Meijerink JP, Soulier J, Van Vlierberghe P, Haigh JJ. Goossens S, et al. Among authors: van der meulen j, van roy n, van vlierberghe p. Nat Commun. 2015 Jan 7;6:5794. doi: 10.1038/ncomms6794. Nat Commun. 2015. PMID: 25565005 Free PMC article.
Characterization of the genome-wide TLX1 binding profile in T-cell acute lymphoblastic leukemia.
Durinck K, Van Loocke W, Van der Meulen J, Van de Walle I, Ongenaert M, Rondou P, Wallaert A, de Bock CE, Van Roy N, Poppe B, Cools J, Soulier J, Taghon T, Speleman F, Van Vlierberghe P. Durinck K, et al. Among authors: van der meulen j, van de walle i, van loocke w, van roy n, van vlierberghe p. Leukemia. 2015 Dec;29(12):2317-27. doi: 10.1038/leu.2015.162. Epub 2015 Jun 25. Leukemia. 2015. PMID: 26108691
Long noncoding RNA signatures define oncogenic subtypes in T-cell acute lymphoblastic leukemia.
Wallaert A, Durinck K, Van Loocke W, Van de Walle I, Matthijssens F, Volders PJ, Avila Cobos F, Rombaut D, Rondou P, Mestdagh P, Vandesompele J, Poppe B, Taghon T, Soulier J, Van Vlierberghe P, Speleman F. Wallaert A, et al. Among authors: van de walle i, van loocke w, van vlierberghe p. Leukemia. 2016 Sep;30(9):1927-30. doi: 10.1038/leu.2016.82. Epub 2016 Apr 22. Leukemia. 2016. PMID: 27168467 No abstract available.
Oncogenic ZEB2 activation drives sensitivity toward KDM1A inhibition in T-cell acute lymphoblastic leukemia.
Goossens S, Peirs S, Van Loocke W, Wang J, Takawy M, Matthijssens F, Sonderegger SE, Haigh K, Nguyen T, Vandamme N, Costa M, Carmichael C, Van Nieuwerburgh F, Deforce D, Kleifeld O, Curtis DJ, Berx G, Van Vlierberghe P, Haigh JJ. Goossens S, et al. Among authors: van nieuwerburgh f, van loocke w, van vlierberghe p. Blood. 2017 Feb 23;129(8):981-990. doi: 10.1182/blood-2016-06-721191. Epub 2017 Jan 9. Blood. 2017. PMID: 28069602 Free PMC article.
Targeting BET proteins improves the therapeutic efficacy of BCL-2 inhibition in T-cell acute lymphoblastic leukemia.
Peirs S, Frismantas V, Matthijssens F, Van Loocke W, Pieters T, Vandamme N, Lintermans B, Dobay MP, Berx G, Poppe B, Goossens S, Bornhauser BC, Bourquin JP, Van Vlierberghe P. Peirs S, et al. Among authors: van loocke w, van vlierberghe p. Leukemia. 2017 Oct;31(10):2037-2047. doi: 10.1038/leu.2017.10. Epub 2017 Jan 11. Leukemia. 2017. PMID: 28074072 Free article.
ZEB2 and LMO2 drive immature T-cell lymphoblastic leukemia via distinct oncogenic mechanisms.
Goossens S, Wang J, Tremblay CS, De Medts J, T'Sas S, Nguyen T, Saw J, Haigh K, Curtis DJ, Van Vlierberghe P, Berx G, Taghon T, Haigh JJ. Goossens S, et al. Among authors: van vlierberghe p. Haematologica. 2019 Aug;104(8):1608-1616. doi: 10.3324/haematol.2018.207837. Epub 2019 Jan 24. Haematologica. 2019. PMID: 30679322 Free PMC article.
Novel strategy for rapid functional in vivo validation of oncogenic drivers in haematological malignancies.
Pieters T, T'Sas S, Demoen L, Almeida A, Haenebalcke L, Matthijssens F, Lemeire K, D'Hont J, Van Rockeghem F, Hochepied T, Lintermans B, Reunes L, Lammens T, Berx G, Haigh JJ, Goossens S, Van Vlierberghe P. Pieters T, et al. Among authors: van rockeghem f, van vlierberghe p. Sci Rep. 2019 Jul 22;9(1):10577. doi: 10.1038/s41598-019-46853-x. Sci Rep. 2019. PMID: 31332244 Free PMC article.
The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1.
Carmichael CL, Wang J, Nguyen T, Kolawole O, Benyoucef A, De Mazière C, Milne AR, Samuel S, Gillinder K, Hediyeh-Zadeh S, Vo ANQ, Huang Y, Knezevic K, McInnes WRL, Shields BJ, Mitchell H, Ritchie ME, Lammens T, Lintermans B, Van Vlierberghe P, Wong NC, Haigh K, Thoms JAI, Toulmin E, Curtis DJ, Oxley EP, Dickins RA, Beck D, Perkins A, McCormack MP, Davis MJ, Berx G, Zuber J, Pimanda JE, Kile BT, Goossens S, Haigh JJ. Carmichael CL, et al. Among authors: van vlierberghe p. Blood. 2020 Aug 20;136(8):957-973. doi: 10.1182/blood.2019002548. Blood. 2020. PMID: 32369597 Free PMC article.
144 results