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Next generation fibroblast activation protein (FAP) targeting PET tracers - The tetrazine ligation allows an easy and convenient way to 18F-labeled (4-quinolinoyl)glycyl-2-cyanopyrrolidines.
Poulie CBM, Shalgunov V, Elvas F, Van Rymenant Y, Moon ES, Battisti UM, De Loose J, De Meester I, Rösch F, Van Der Veken P, Herth MM. Poulie CBM, et al. Among authors: van rymenant y. Eur J Med Chem. 2023 Dec 15;262:115862. doi: 10.1016/j.ejmech.2023.115862. Epub 2023 Oct 14. Eur J Med Chem. 2023. PMID: 37883899 Free article.
Druglike, 18F-labeled PET Tracers Targeting Fibroblast Activation Protein.
Tanc M, Filippi N, Van Rymenant Y, Grintsevich S, Pintelon I, Verschuuren M, De Loose J, Verhulst E, Moon ES, Cianni L, Stroobants S, Augustyns K, Roesch F, De Meester I, Elvas F, Van der Veken P. Tanc M, et al. Among authors: van rymenant y. J Med Chem. 2024 May 9;67(9):7068-7087. doi: 10.1021/acs.jmedchem.3c02402. Epub 2024 Apr 24. J Med Chem. 2024. PMID: 38656144
Active site-directed probes targeting dipeptidyl peptidases 8 and 9.
Espadinha M, De Loose J, Corthaut S, Thys S, Van Rymenant Y, Verhulst E, Benramdane S, Filippi N, Augustyns K, Van Wielendaele P, Pintelon I, De Meester I, Van der Veken P. Espadinha M, et al. Among authors: van rymenant y. Eur J Med Chem. 2024 Apr 15;270:116389. doi: 10.1016/j.ejmech.2024.116389. Epub 2024 Apr 3. Eur J Med Chem. 2024. PMID: 38593588