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Development of resistance against diketo derivatives of human immunodeficiency virus type 1 by progressive accumulation of integrase mutations.
Fikkert V, Van Maele B, Vercammen J, Hantson A, Van Remoortel B, Michiels M, Gurnari C, Pannecouque C, De Maeyer M, Engelborghs Y, De Clercq E, Debyser Z, Witvrouw M. Fikkert V, et al. Among authors: van maele b, van remoortel b. J Virol. 2003 Nov;77(21):11459-70. doi: 10.1128/jvi.77.21.11459-11470.2003. J Virol. 2003. PMID: 14557631 Free PMC article.
env chimeric virus technology for evaluating human immunodeficiency virus susceptibility to entry inhibitors.
Fikkert V, Cherepanov P, Van Laethem K, Hantson A, Van Remoortel B, Pannecouque C, De Clercq E, Debyser Z, Vandamme AM, Witvrouw M. Fikkert V, et al. Among authors: van laethem k, van remoortel b. Antimicrob Agents Chemother. 2002 Dec;46(12):3954-62. doi: 10.1128/AAC.46.12.3954-3962.2002. Antimicrob Agents Chemother. 2002. PMID: 12435701 Free PMC article.
Mutations in both env and gag genes are required for HIV-1 resistance to the polysulfonic dendrimer SPL2923, as corroborated by chimeric virus technology.
Hantson A, Fikkert V, Van Remoortel B, Pannecouque C, Cherepanov P, Matthews B, Holan G, De Clercq E, Vandamme AM, Debyser Z, Witvrouw M. Hantson A, et al. Among authors: van remoortel b. Antivir Chem Chemother. 2005;16(4):253-66. doi: 10.1177/095632020501600405. Antivir Chem Chemother. 2005. PMID: 16130523 Free article.
Mutations in human immunodeficiency virus type 1 integrase confer resistance to the naphthyridine L-870,810 and cross-resistance to the clinical trial drug GS-9137.
Hombrouck A, Voet A, Van Remoortel B, Desadeleer C, De Maeyer M, Debyser Z, Witvrouw M. Hombrouck A, et al. Among authors: van remoortel b. Antimicrob Agents Chemother. 2008 Jun;52(6):2069-78. doi: 10.1128/AAC.00911-07. Epub 2008 Mar 31. Antimicrob Agents Chemother. 2008. PMID: 18378713 Free PMC article.
Preclinical evaluation of 1H-benzylindole derivatives as novel human immunodeficiency virus integrase strand transfer inhibitors.
Hombrouck A, Van Remoortel B, Michiels M, Noppe W, Christ F, Eneroth A, Sahlberg BL, Benkestock K, Vrang L, Johansson NG, Barreca ML, De Luca L, Ferro S, Chimirri A, Debyser Z, Witvrouw M. Hombrouck A, et al. Among authors: van remoortel b. Antimicrob Agents Chemother. 2008 Aug;52(8):2861-9. doi: 10.1128/AAC.00210-08. Epub 2008 Jun 9. Antimicrob Agents Chemother. 2008. PMID: 18541726 Free PMC article.
Selection of human immunodeficiency virus type 1 resistance against the pyranodipyrimidine V-165 points to a multimodal mechanism of action.
Hombrouck A, Hantson A, van Remoortel B, Michiels M, Vercammen J, Rhodes D, Tetz V, Engelborghs Y, Christ F, Debyser Z, Witvrouw M. Hombrouck A, et al. Among authors: van remoortel b. J Antimicrob Chemother. 2007 Jun;59(6):1084-95. doi: 10.1093/jac/dkm101. Epub 2007 Apr 30. J Antimicrob Chemother. 2007. PMID: 17470918
Multiple drug resistance to nucleoside analogues and nonnucleoside reverse transcriptase inhibitors in an efficiently replicating human immunodeficiency virus type 1 patient strain.
Schmit JC, Cogniaux J, Hermans P, Van Vaeck C, Sprecher S, Van Remoortel B, Witvrouw M, Balzarini J, Desmyter J, De Clercq E, Vandamme AM. Schmit JC, et al. Among authors: van vaeck c, van remoortel b. J Infect Dis. 1996 Nov;174(5):962-8. doi: 10.1093/infdis/174.5.962. J Infect Dis. 1996. PMID: 8896496
17 results