Van Petegem F - Search Results

1

Cryo-EM structures of the ABCA4 importer reveal mechanisms underlying substrate binding and Stargardt disease.

Scortecci JF, Molday LL, Curtis SB, Garces FA, Panwar P, Van Petegem F, Molday RS. Scortecci JF, et al. Among authors: van petegem f. Nat Commun. 2021 Oct 8;12(1):5902. doi: 10.1038/s41467-021-26161-7. Nat Commun. 2021. PMID: 34625547 Free PMC article.

2

The amino-terminal disease hotspot of ryanodine receptors forms a cytoplasmic vestibule.

Tung CC, Lobo PA, Kimlicka L, Van Petegem F. Tung CC, et al. Among authors: van petegem f. Nature. 2010 Nov 25;468(7323):585-8. doi: 10.1038/nature09471. Epub 2010 Nov 3. Nature. 2010. PMID: 21048710

3

Disease mutations in the ryanodine receptor N-terminal region couple to a mobile intersubunit interface.

Kimlicka L, Lau K, Tung CC, Van Petegem F. Kimlicka L, et al. Among authors: van petegem f. Nat Commun. 2013;4:1506. doi: 10.1038/ncomms2501. Nat Commun. 2013. PMID: 23422674 Free PMC article.

4

Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain.

Lau K, Van Petegem F. Lau K, et al. Among authors: van petegem f. Nat Commun. 2014 Nov 5;5:5397. doi: 10.1038/ncomms6397. Nat Commun. 2014. PMID: 25370123 Free article.

5

Crystal structures of ryanodine receptor SPRY1 and tandem-repeat domains reveal a critical FKBP12 binding determinant.

Yuchi Z, Yuen SM, Lau K, Underhill AQ, Cornea RL, Fessenden JD, Van Petegem F. Yuchi Z, et al. Among authors: van petegem f. Nat Commun. 2015 Aug 6;6:7947. doi: 10.1038/ncomms8947. Nat Commun. 2015. PMID: 26245150 Free PMC article.

6

Type 8 long QT syndrome: pathogenic variants in CACNA1C-encoded Cav1.2 cluster in STAC protein binding site.

Mellor GJ, Panwar P, Lee AK, Steinberg C, Hathaway JA, Bartels K, Christian S, Balaji S, Roberts JD, Simpson CS, Boczek NJ, Tester DJ, Radbill AE, Mok NS, Hamilton RM, Kaufman ES, Eugenio PL, Weiss R, January C, McDaniel GM, Leather RA, Erickson C, Falik S, Behr ER, Wilde AAM, Sanatani S, Ackerman MJ, Van Petegem F, Krahn AD, Laksman Z. Mellor GJ, et al. Among authors: van petegem f. Europace. 2019 Nov 1;21(11):1725-1732. doi: 10.1093/europace/euz215. Europace. 2019. PMID: 31408100

7

Cardiac ryanodine receptor distribution is dynamic and changed by auxiliary proteins and post-translational modification.

Asghari P, Scriven DR, Ng M, Panwar P, Chou KC, van Petegem F, Moore ED. Asghari P, et al. Among authors: van petegem f. Elife. 2020 Jan 9;9:e51602. doi: 10.7554/eLife.51602. Elife. 2020. PMID: 31916935 Free PMC article.

8

Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM.

Woll KA, Haji-Ghassemi O, Van Petegem F. Woll KA, et al. Among authors: van petegem f. Nat Commun. 2021 Feb 5;12(1):807. doi: 10.1038/s41467-021-21141-3. Nat Commun. 2021. PMID: 33547325 Free PMC article.

9

Structures of the junctophilin/voltage-gated calcium channel interface reveal hot spot for cardiomyopathy mutations.

Yang ZF, Panwar P, McFarlane CR, Tuinte WE, Campiglio M, Van Petegem F. Yang ZF, et al. Among authors: van petegem f. Proc Natl Acad Sci U S A. 2022 Mar 8;119(10):e2120416119. doi: 10.1073/pnas.2120416119. Epub 2022 Mar 1. Proc Natl Acad Sci U S A. 2022. PMID: 35238659 Free PMC article.

10

Structural and electrophysiological basis for the modulation of KCNQ1 channel currents by ML277.

Willegems K, Eldstrom J, Kyriakis E, Ataei F, Sahakyan H, Dou Y, Russo S, Van Petegem F, Fedida D. Willegems K, et al. Among authors: van petegem f. Nat Commun. 2022 Jun 29;13(1):3760. doi: 10.1038/s41467-022-31526-7. Nat Commun. 2022. PMID: 35768468 Free PMC article.

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