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Integrity and efficiency: AbbVie's journey of building an integrated nonregulated bioanalytical laboratory.
Bioanalysis. 2023 Feb;15(3):161-176. doi: 10.4155/bio-2023-0012. Epub 2023 Mar 24.
Bioanalysis. 2023.
PMID: 36961367
Review.
Prodrug Strategies to Improve the Solubility of the HCV NS5A Inhibitor Pibrentasvir (ABT-530).
Randolph JT, Voight EA, Greszler SN, Uno BE, Newton JN, Gleason KM, Stolarik D, Van Handel C, Bow DAJ, DeGoey DA.
Randolph JT, et al. Among authors: van handel c.
J Med Chem. 2020 Oct 8;63(19):11034-11044. doi: 10.1021/acs.jmedchem.0c00956. Epub 2020 Sep 17.
J Med Chem. 2020.
PMID: 32881503
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Discovery of 2-aminoisobutyric acid ethyl ester (AIBEE) phosphoramidate prodrugs for delivering nucleoside HCV NS5B polymerase inhibitors.
Randolph JT, Li T, Chris Krueger A, Heyman HR, Chen HJ, Bow DAJ, Van Handel C, Peterkin V, Carr RA, Stolarik D, Dekhtyar T, Irvin M, Krishnan P, Wagner R, DeGoey DA.
Randolph JT, et al. Among authors: van handel c.
Bioorg Med Chem Lett. 2020 Apr 1;30(7):126986. doi: 10.1016/j.bmcl.2020.126986. Epub 2020 Jan 25.
Bioorg Med Chem Lett. 2020.
PMID: 32046903
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Synthesis and evaluation of 2'-dihalo ribonucleotide prodrugs with activity against hepatitis C virus.
Chris Krueger A, Chen HJ, Randolph JT, Brown BS, Halvorsen GT, Heyman HR, Li T, Marvin CC, Shanley JP, Voight EA, Bow DAJ, Van Handel C, Peterkin V, Carr RA, Stolarik D, Dekhtyar T, Irvin ML, Krishnan P, Henry RF, Wagner R, DeGoey DA.
Chris Krueger A, et al. Among authors: van handel c.
Bioorg Med Chem. 2020 Jan 1;28(1):115208. doi: 10.1016/j.bmc.2019.115208. Epub 2019 Nov 11.
Bioorg Med Chem. 2020.
PMID: 31740203
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Structure-activity studies of diazabicyclo[3.3.0]octane-substituted pyrazines and pyridines as potent α4β2 nicotinic acetylcholine receptor ligands.
Scanio MJ, Shi L, Bunnelle WH, Anderson DJ, Helfrich RJ, Malysz J, Thorin-Hagene KK, Van Handel CE, Marsh KC, Lee CH, Gopalakrishnan M.
Scanio MJ, et al. Among authors: van handel ce.
J Med Chem. 2011 Nov 10;54(21):7678-92. doi: 10.1021/jm201045m. Epub 2011 Oct 11.
J Med Chem. 2011.
PMID: 21962147
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