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Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity.
Vriens K, Christen S, Parik S, Broekaert D, Yoshinaga K, Talebi A, Dehairs J, Escalona-Noguero C, Schmieder R, Cornfield T, Charlton C, Romero-Pérez L, Rossi M, Rinaldi G, Orth MF, Boon R, Kerstens A, Kwan SY, Faubert B, Méndez-Lucas A, Kopitz CC, Chen T, Fernandez-Garcia J, Duarte JAG, Schmitz AA, Steigemann P, Najimi M, Hägebarth A, Van Ginderachter JA, Sokal E, Gotoh N, Wong KK, Verfaillie C, Derua R, Munck S, Yuneva M, Beretta L, DeBerardinis RJ, Swinnen JV, Hodson L, Cassiman D, Verslype C, Christian S, Grünewald S, Grünewald TGP, Fendt SM. Vriens K, et al. Among authors: van ginderachter ja. Nature. 2019 Feb;566(7744):403-406. doi: 10.1038/s41586-019-0904-1. Epub 2019 Feb 6. Nature. 2019. PMID: 30728499 Free PMC article.
The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity.
Laoui D, Keirsse J, Morias Y, Van Overmeire E, Geeraerts X, Elkrim Y, Kiss M, Bolli E, Lahmar Q, Sichien D, Serneels J, Scott CL, Boon L, De Baetselier P, Mazzone M, Guilliams M, Van Ginderachter JA. Laoui D, et al. Among authors: van ginderachter ja, van overmeire e. Nat Commun. 2016 Dec 23;7:13720. doi: 10.1038/ncomms13720. Nat Commun. 2016. PMID: 28008905 Free PMC article.
Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization.
Pombo Antunes AR, Scheyltjens I, Lodi F, Messiaen J, Antoranz A, Duerinck J, Kancheva D, Martens L, De Vlaminck K, Van Hove H, Kjølner Hansen SS, Bosisio FM, Van der Borght K, De Vleeschouwer S, Sciot R, Bouwens L, Verfaillie M, Vandamme N, Vandenbroucke RE, De Wever O, Saeys Y, Guilliams M, Gysemans C, Neyns B, De Smet F, Lambrechts D, Van Ginderachter JA, Movahedi K. Pombo Antunes AR, et al. Among authors: van ginderachter ja, van hove h, van der borght k. Nat Neurosci. 2021 Apr;24(4):595-610. doi: 10.1038/s41593-020-00789-y. Epub 2021 Mar 29. Nat Neurosci. 2021. PMID: 33782623
Macrophages are metabolically heterogeneous within the tumor microenvironment.
Geeraerts X, Fernández-Garcia J, Hartmann FJ, de Goede KE, Martens L, Elkrim Y, Debraekeleer A, Stijlemans B, Vandekeere A, Rinaldi G, De Rycke R, Planque M, Broekaert D, Meinster E, Clappaert E, Bardet P, Murgaski A, Gysemans C, Nana FA, Saeys Y, Bendall SC, Laoui D, Van den Bossche J, Fendt SM, Van Ginderachter JA. Geeraerts X, et al. Among authors: van den bossche j, van ginderachter ja. Cell Rep. 2021 Dec 28;37(13):110171. doi: 10.1016/j.celrep.2021.110171. Cell Rep. 2021. PMID: 34965415 Free article.
GBM tumors are heterogeneous in their fatty acid metabolism and modulating fatty acid metabolism sensitizes cancer cells derived from recurring GBM tumors to temozolomide.
Parik S, Fernández-García J, Lodi F, De Vlaminck K, Derweduwe M, De Vleeschouwer S, Sciot R, Geens W, Weng L, Bosisio FM, Bergers G, Duerinck J, De Smet F, Lambrechts D, Van Ginderachter JA, Fendt SM. Parik S, et al. Among authors: van ginderachter ja. Front Oncol. 2022 Sep 23;12:988872. doi: 10.3389/fonc.2022.988872. eCollection 2022. Front Oncol. 2022. PMID: 36338708 Free PMC article.
A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment.
Van Hove H, Martens L, Scheyltjens I, De Vlaminck K, Pombo Antunes AR, De Prijck S, Vandamme N, De Schepper S, Van Isterdael G, Scott CL, Aerts J, Berx G, Boeckxstaens GE, Vandenbroucke RE, Vereecke L, Moechars D, Guilliams M, Van Ginderachter JA, Saeys Y, Movahedi K. Van Hove H, et al. Among authors: van ginderachter ja, van isterdael g. Nat Neurosci. 2019 Jun;22(6):1021-1035. doi: 10.1038/s41593-019-0393-4. Epub 2019 May 6. Nat Neurosci. 2019. PMID: 31061494
Single-cell RNA and protein profiling of immune cells from the mouse brain and its border tissues.
Scheyltjens I, Van Hove H, De Vlaminck K, Kancheva D, Bastos J, Vara-Pérez M, Pombo Antunes AR, Martens L, Scott CL, Van Ginderachter JA, Saeys Y, Guilliams M, Vandamme N, Movahedi K. Scheyltjens I, et al. Among authors: van ginderachter ja, van hove h. Nat Protoc. 2022 Oct;17(10):2354-2388. doi: 10.1038/s41596-022-00716-4. Epub 2022 Aug 5. Nat Protoc. 2022. PMID: 35931780 Review.
152 results