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Protective effects of the succinate/SUCNR1 axis on damaged hepatocytes in NAFLD.
Marsal-Beltran A, Rodríguez-Castellano A, Astiarraga B, Calvo E, Rada P, Madeira A, Rodríguez-Peña MM, Llauradó G, Núñez-Roa C, Gómez-Santos B, Maymó-Masip E, Bosch R, Frutos MD, Moreno-Navarrete JM, Ramos-Molina B, Aspichueta P, Joven J, Fernández-Real JM, Quer JC, Valverde ÁM, Pardo A, Vendrell J, Ceperuelo-Mallafré V, Fernández-Veledo S. Marsal-Beltran A, et al. Among authors: valverde am. Metabolism. 2023 Aug;145:155630. doi: 10.1016/j.metabol.2023.155630. Epub 2023 Jun 13. Metabolism. 2023. PMID: 37315889 Free article.
Protein tyrosine phosphatase 1B modulates GSK3β/Nrf2 and IGFIR signaling pathways in acetaminophen-induced hepatotoxicity.
Mobasher MA, González-Rodriguez A, Santamaría B, Ramos S, Martín MÁ, Goya L, Rada P, Letzig L, James LP, Cuadrado A, Martín-Pérez J, Simpson KJ, Muntané J, Valverde AM. Mobasher MA, et al. Among authors: valverde am. Cell Death Dis. 2013 May 9;4(5):e626. doi: 10.1038/cddis.2013.150. Cell Death Dis. 2013. PMID: 23661004 Free PMC article.
A positive feedback loop between AMPK and GDF15 promotes metformin antidiabetic effects.
Aguilar-Recarte D, Barroso E, Zhang M, Rada P, Pizarro-Delgado J, Peña L, Palomer X, Valverde ÁM, Wahli W, Vázquez-Carrera M. Aguilar-Recarte D, et al. Among authors: valverde am. Pharmacol Res. 2023 Jan;187:106578. doi: 10.1016/j.phrs.2022.106578. Epub 2022 Nov 23. Pharmacol Res. 2023. PMID: 36435271 Free article.
"MiR-7 controls cholesterol biosynthesis through posttranscriptional regulation of DHCR24 expression".
Frutos MF, Pardo-Marqués V, Torrecilla-Parra M, Rada P, Pérez-García A, Martín-Martín Y, de la Peña G, Gómez A, Toledano-Zaragoza A, Gómez-Coronado D, Casarejos MJ, Solís JM, Rotllan N, Pastor Ó, Ledesma MD, Valverde ÁM, Busto R, Ramírez CM. Frutos MF, et al. Among authors: valverde am. Biochim Biophys Acta Gene Regul Mech. 2023 Jun;1866(2):194938. doi: 10.1016/j.bbagrm.2023.194938. Epub 2023 Apr 21. Biochim Biophys Acta Gene Regul Mech. 2023. PMID: 37086967
Hypothalamic JNK1-hepatic fatty acid synthase axis mediates a metabolic rewiring that prevents hepatic steatosis in male mice treated with olanzapine via intraperitoneal: Additional effects of PTP1B inhibition.
Ferreira V, Folgueira C, García-Altares M, Guillén M, Ruíz-Rosario M, DiNunzio G, Garcia-Martinez I, Alen R, Bookmeyer C, Jones JG, Cigudosa JC, López-Larrubia P, Correig-Blanchar X, Davis RJ, Sabio G, Rada P, Valverde ÁM. Ferreira V, et al. Among authors: valverde am. Redox Biol. 2023 Jul;63:102741. doi: 10.1016/j.redox.2023.102741. Epub 2023 May 15. Redox Biol. 2023. PMID: 37230004 Free PMC article.
Elafibranor upregulates the EMT-inducer S100A4 via PPARβ/δ.
Zhang M, Barroso E, Ruart M, Peña L, Peyman M, Aguilar-Recarte D, Montori-Grau M, Rada P, Cugat C, Montironi C, Zarei M, Jurado-Aguilar J, Camins A, Balsinde J, Valverde ÁM, Wahli W, Palomer X, Vázquez-Carrera M. Zhang M, et al. Among authors: valverde am. Biomed Pharmacother. 2023 Nov;167:115623. doi: 10.1016/j.biopha.2023.115623. Epub 2023 Sep 30. Biomed Pharmacother. 2023. PMID: 37783154 Free article.
Soluble epoxide hydrolase-targeting PROTAC activates AMPK and inhibits endoplasmic reticulum stress.
Peyman M, Barroso E, Turcu AL, Estrany F Jr, Smith D, Jurado-Aguilar J, Rada P, Morisseau C, Hammock BD, Valverde ÁM, Palomer X, Galdeano C, Vázquez S, Vázquez-Carrera M. Peyman M, et al. Among authors: valverde am. Biomed Pharmacother. 2023 Dec;168:115667. doi: 10.1016/j.biopha.2023.115667. Epub 2023 Oct 10. Biomed Pharmacother. 2023. PMID: 37826940 Free article.
Specific targeting of the NRF2/β-TrCP axis promotes beneficial effects in NASH.
Fernández-Ginés R, Encinar JA, Escoll M, Carnicero-Senabre D, Jiménez-Villegas J, García-Yagüe ÁJ, González-Rodríguez Á, Garcia-Martinez I, Valverde ÁM, Rojo AI, Cuadrado A. Fernández-Ginés R, et al. Among authors: valverde am. Redox Biol. 2024 Feb;69:103027. doi: 10.1016/j.redox.2024.103027. Epub 2024 Jan 3. Redox Biol. 2024. PMID: 38184999 Free PMC article.
Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD.
González-Rodríguez A, Mayoral R, Agra N, Valdecantos MP, Pardo V, Miquilena-Colina ME, Vargas-Castrillón J, Lo Iacono O, Corazzari M, Fimia GM, Piacentini M, Muntané J, Boscá L, García-Monzón C, Martín-Sanz P, Valverde ÁM. González-Rodríguez A, et al. Among authors: valverde am. Cell Death Dis. 2014 Apr 17;5(4):e1179. doi: 10.1038/cddis.2014.162. Cell Death Dis. 2014. PMID: 24743734 Free PMC article.
194 results