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A New Strategy for Glioblastoma Treatment: In Vitro and In Vivo Preclinical Characterization of Si306, a Pyrazolo[3,4-d]Pyrimidine Dual Src/P-Glycoprotein Inhibitor.
Fallacara AL, Zamperini C, Podolski-Renić A, Dinić J, Stanković T, Stepanović M, Mancini A, Rango E, Iovenitti G, Molinari A, Bugli F, Sanguinetti M, Torelli R, Martini M, Maccari L, Valoti M, Dreassi E, Botta M, Pešić M, Schenone S. Fallacara AL, et al. Among authors: valoti m. Cancers (Basel). 2019 Jun 19;11(6):848. doi: 10.3390/cancers11060848. Cancers (Basel). 2019. PMID: 31248184 Free PMC article.
Prodrugs of Pyrazolo[3,4-d]pyrimidines: From Library Synthesis to Evaluation as Potential Anticancer Agents in an Orthotopic Glioblastoma Model.
Vignaroli G, Iovenitti G, Zamperini C, Coniglio F, Calandro P, Molinari A, Fallacara AL, Sartucci A, Calgani A, Colecchia D, Mancini A, Festuccia C, Dreassi E, Valoti M, Musumeci F, Chiariello M, Angelucci A, Botta M, Schenone S. Vignaroli G, et al. Among authors: valoti m. J Med Chem. 2017 Jul 27;60(14):6305-6320. doi: 10.1021/acs.jmedchem.7b00637. Epub 2017 Jul 18. J Med Chem. 2017. PMID: 28650650
The Pyrazolo[3,4-d]Pyrimidine Derivative Si306 Encapsulated into Anti-GD2-Immunoliposomes as Therapeutic Treatment of Neuroblastoma.
Rango E, Pastorino F, Brignole C, Mancini A, Poggialini F, Di Maria S, Zamperini C, Iovenitti G, Fallacara AL, Sabetta S, Clementi L, Valoti M, Schenone S, Angelucci A, Ponzoni M, Dreassi E, Botta M. Rango E, et al. Among authors: valoti m. Biomedicines. 2022 Mar 12;10(3):659. doi: 10.3390/biomedicines10030659. Biomedicines. 2022. PMID: 35327462 Free PMC article.
Design, synthesis, biological activity, and ADME properties of pyrazolo[3,4-d]pyrimidines active in hypoxic human leukemia cells: a lead optimization study.
Radi M, Dreassi E, Brullo C, Crespan E, Tintori C, Bernardo V, Valoti M, Zamperini C, Daigl H, Musumeci F, Carraro F, Naldini A, Filippi I, Maga G, Schenone S, Botta M. Radi M, et al. Among authors: valoti m. J Med Chem. 2011 Apr 28;54(8):2610-26. doi: 10.1021/jm1012819. Epub 2011 Mar 28. J Med Chem. 2011. PMID: 21443205
Antihypertensive, cardio- and neuro-protective effects of Tenebrio molitor (Coleoptera: Tenebrionidae) defatted larvae in spontaneously hypertensive rats.
Pessina F, Frosini M, Marcolongo P, Fusi F, Saponara S, Gamberucci A, Valoti M, Giustarini D, Fiorenzani P, Gorelli B, Francardi V, Botta M, Dreassi E. Pessina F, et al. Among authors: valoti m. PLoS One. 2020 May 29;15(5):e0233788. doi: 10.1371/journal.pone.0233788. eCollection 2020. PLoS One. 2020. PMID: 32470081 Free PMC article.
Reversible Monoacylglycerol Lipase Inhibitors: Discovery of a New Class of Benzylpiperidine Derivatives.
Bononi G, Di Stefano M, Poli G, Ortore G, Meier P, Masetto F, Caligiuri I, Rizzolio F, Macchia M, Chicca A, Avan A, Giovannetti E, Vagaggini C, Brai A, Dreassi E, Valoti M, Minutolo F, Granchi C, Gertsch J, Tuccinardi T. Bononi G, et al. Among authors: valoti m. J Med Chem. 2022 May 26;65(10):7118-7140. doi: 10.1021/acs.jmedchem.1c01806. Epub 2022 May 6. J Med Chem. 2022. PMID: 35522977 Free PMC article.
116 results