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2-Propargylamino-naphthoquinone derivatives as multipotent agents for the treatment of Alzheimer's disease.
Mezeiova E, Janockova J, Andrys R, Soukup O, Kobrlova T, Muckova L, Pejchal J, Simunkova M, Handl J, Micankova P, Capek J, Rousar T, Hrabinova M, Nepovimova E, Marco-Contelles JL, Valko M, Korabecny J. Mezeiova E, et al. Among authors: valko m. Eur J Med Chem. 2021 Feb 5;211:113112. doi: 10.1016/j.ejmech.2020.113112. Epub 2020 Dec 18. Eur J Med Chem. 2021. PMID: 33360800
Targeting copper(II)-induced oxidative stress and the acetylcholinesterase system in Alzheimer's disease using multifunctional tacrine-coumarin hybrid molecules.
Hamulakova S, Poprac P, Jomova K, Brezova V, Lauro P, Drostinova L, Jun D, Sepsova V, Hrabinova M, Soukup O, Kristian P, Gazova Z, Bednarikova Z, Kuca K, Valko M. Hamulakova S, et al. Among authors: valko m. J Inorg Biochem. 2016 Aug;161:52-62. doi: 10.1016/j.jinorgbio.2016.05.001. Epub 2016 May 5. J Inorg Biochem. 2016. PMID: 27230386
Targeting Free Radicals in Oxidative Stress-Related Human Diseases.
Poprac P, Jomova K, Simunkova M, Kollar V, Rhodes CJ, Valko M. Poprac P, et al. Among authors: valko m. Trends Pharmacol Sci. 2017 Jul;38(7):592-607. doi: 10.1016/j.tips.2017.04.005. Epub 2017 May 24. Trends Pharmacol Sci. 2017. PMID: 28551354 Review.
Redox-cycling and intercalating properties of novel mixed copper(II) complexes with non-steroidal anti-inflammatory drugs tolfenamic, mefenamic and flufenamic acids and phenanthroline functionality: Structure, SOD-mimetic activity, interaction with albumin, DNA damage study and anticancer activity.
Simunkova M, Lauro P, Jomova K, Hudecova L, Danko M, Alwasel S, Alhazza IM, Rajcaniova S, Kozovska Z, Kucerova L, Moncol J, Svorc L, Valko M. Simunkova M, et al. Among authors: valko m. J Inorg Biochem. 2019 May;194:97-113. doi: 10.1016/j.jinorgbio.2019.02.010. Epub 2019 Feb 23. J Inorg Biochem. 2019. PMID: 30849593
A Switch between Antioxidant and Prooxidant Properties of the Phenolic Compounds Myricetin, Morin, 3',4'-Dihydroxyflavone, Taxifolin and 4-Hydroxy-Coumarin in the Presence of Copper(II) Ions: A Spectroscopic, Absorption Titration and DNA Damage Study.
Jomová K, Hudecova L, Lauro P, Simunkova M, Alwasel SH, Alhazza IM, Valko M. Jomová K, et al. Among authors: valko m. Molecules. 2019 Nov 27;24(23):4335. doi: 10.3390/molecules24234335. Molecules. 2019. PMID: 31783535 Free PMC article.
Pursuing the Complexity of Alzheimer's Disease: Discovery of Fluoren-9-Amines as Selective Butyrylcholinesterase Inhibitors and N-Methyl-d-Aspartate Receptor Antagonists.
Konecny J, Misiachna A, Hrabinova M, Pulkrabkova L, Benkova M, Prchal L, Kucera T, Kobrlova T, Finger V, Kolcheva M, Kortus S, Jun D, Valko M, Horak M, Soukup O, Korabecny J. Konecny J, et al. Among authors: valko m. Biomolecules. 2020 Dec 22;11(1):3. doi: 10.3390/biom11010003. Biomolecules. 2020. PMID: 33375115 Free PMC article.
80 results