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Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.
Figueroa ME, Abdel-Wahab O, Lu C, Ward PS, Patel J, Shih A, Li Y, Bhagwat N, Vasanthakumar A, Fernandez HF, Tallman MS, Sun Z, Wolniak K, Peeters JK, Liu W, Choe SE, Fantin VR, Paietta E, Löwenberg B, Licht JD, Godley LA, Delwel R, Valk PJ, Thompson CB, Levine RL, Melnick A. Figueroa ME, et al. Among authors: valk pj. Cancer Cell. 2010 Dec 14;18(6):553-67. doi: 10.1016/j.ccr.2010.11.015. Epub 2010 Dec 9. Cancer Cell. 2010. PMID: 21130701 Free PMC article.
Leukemic predisposition of pSca-1/Cb2 transgenic mice.
Joosten M, Valk PJ, Jordà MA, Vankan-Berkhoudt Y, Verbakel S, van den Broek M, Beijen A, Löwenberg B, Delwel R. Joosten M, et al. Among authors: valk pj. Exp Hematol. 2002 Feb;30(2):142-9. doi: 10.1016/s0301-472x(01)00779-2. Exp Hematol. 2002. PMID: 11823049 Free article.
High EVI1 expression predicts poor survival in acute myeloid leukemia: a study of 319 de novo AML patients.
Barjesteh van Waalwijk van Doorn-Khosrovani S, Erpelinck C, van Putten WL, Valk PJ, van der Poel-van de Luytgaarde S, Hack R, Slater R, Smit EM, Beverloo HB, Verhoef G, Verdonck LF, Ossenkoppele GJ, Sonneveld P, de Greef GE, Löwenberg B, Delwel R. Barjesteh van Waalwijk van Doorn-Khosrovani S, et al. Among authors: valk pj. Blood. 2003 Feb 1;101(3):837-45. doi: 10.1182/blood-2002-05-1459. Epub 2002 Oct 3. Blood. 2003. PMID: 12393383 Free article.
226 results