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A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death.
Cell Chem Biol. 2021 Jun 17;28(6):835-847.e5. doi: 10.1016/j.chembiol.2021.02.006. Epub 2021 Mar 3.
Cell Chem Biol. 2021.
PMID: 33662256
Free PMC article.
Quantitation of ERK1/2 inhibitor cellular target occupancies with a reversible slow off-rate probe.
Lebraud H, Surova O, Courtin A, O'Reilly M, Valenzano CR, Nordlund P, Heightman TD.
Lebraud H, et al. Among authors: valenzano cr.
Chem Sci. 2018 Sep 17;9(45):8608-8618. doi: 10.1039/c8sc02754d. eCollection 2018 Dec 7.
Chem Sci. 2018.
PMID: 30568786
Free PMC article.
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Discovery of a junctional epitope antibody that stabilizes IL-6 and gp80 protein:protein interaction and modulates its downstream signaling.
Adams R, Burnley RJ, Valenzano CR, Qureshi O, Doyle C, Lumb S, Del Carmen Lopez M, Griffin R, McMillan D, Taylor RD, Meier C, Mori P, Griffin LM, Wernery U, Kinne J, Rapecki S, Baker TS, Lawson AD, Wright M, Ettorre A.
Adams R, et al. Among authors: valenzano cr.
Sci Rep. 2017 Jan 30;7:37716. doi: 10.1038/srep37716.
Sci Rep. 2017.
PMID: 28134246
Free PMC article.
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Stereospecificity of the dehydratase domain of the erythromycin polyketide synthase.
Valenzano CR, You YO, Garg A, Keatinge-Clay A, Khosla C, Cane DE.
Valenzano CR, et al.
J Am Chem Soc. 2010 Oct 27;132(42):14697-9. doi: 10.1021/ja107344h.
J Am Chem Soc. 2010.
PMID: 20925342
Free PMC article.
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Mechanism and stereospecificity of a fully saturating polyketide synthase module: nanchangmycin synthase module 2 and its dehydratase domain.
Guo X, Liu T, Valenzano CR, Deng Z, Cane DE.
Guo X, et al. Among authors: valenzano cr.
J Am Chem Soc. 2010 Oct 27;132(42):14694-6. doi: 10.1021/ja1073432.
J Am Chem Soc. 2010.
PMID: 20925339
Free PMC article.
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The biochemical basis for stereochemical control in polyketide biosynthesis.
Valenzano CR, Lawson RJ, Chen AY, Khosla C, Cane DE.
Valenzano CR, et al.
J Am Chem Soc. 2009 Dec 30;131(51):18501-11. doi: 10.1021/ja908296m.
J Am Chem Soc. 2009.
PMID: 19928853
Free PMC article.
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Stereospecificity of ketoreductase domains 1 and 2 of the tylactone modular polyketide synthase.
Castonguay R, Valenzano CR, Chen AY, Keatinge-Clay A, Khosla C, Cane DE.
Castonguay R, et al. Among authors: valenzano cr.
J Am Chem Soc. 2008 Sep 3;130(35):11598-9. doi: 10.1021/ja804453p. Epub 2008 Aug 12.
J Am Chem Soc. 2008.
PMID: 18693734
Free PMC article.
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