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Detergent-insoluble aggregates associated with amyotrophic lateral sclerosis in transgenic mice contain primarily full-length, unmodified superoxide dismutase-1.
Shaw BF, Lelie HL, Durazo A, Nersissian AM, Xu G, Chan PK, Gralla EB, Tiwari A, Hayward LJ, Borchelt DR, Valentine JS, Whitelegge JP. Shaw BF, et al. Among authors: valentine js. J Biol Chem. 2008 Mar 28;283(13):8340-50. doi: 10.1074/jbc.M707751200. Epub 2008 Jan 11. J Biol Chem. 2008. PMID: 18192269 Free PMC article.
Dimer destabilization in superoxide dismutase may result in disease-causing properties: structures of motor neuron disease mutants.
Hough MA, Grossmann JG, Antonyuk SV, Strange RW, Doucette PA, Rodriguez JA, Whitson LJ, Hart PJ, Hayward LJ, Valentine JS, Hasnain SS. Hough MA, et al. Among authors: valentine js. Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):5976-81. doi: 10.1073/pnas.0305143101. Epub 2004 Mar 31. Proc Natl Acad Sci U S A. 2004. PMID: 15056757 Free PMC article.
Binding of a single zinc ion to one subunit of copper-zinc superoxide dismutase apoprotein substantially influences the structure and stability of the entire homodimeric protein.
Potter SZ, Zhu H, Shaw BF, Rodriguez JA, Doucette PA, Sohn SH, Durazo A, Faull KF, Gralla EB, Nersissian AM, Valentine JS. Potter SZ, et al. Among authors: valentine js. J Am Chem Soc. 2007 Apr 18;129(15):4575-83. doi: 10.1021/ja066690+. Epub 2007 Mar 24. J Am Chem Soc. 2007. PMID: 17381088
Initiation and elongation in fibrillation of ALS-linked superoxide dismutase.
Chattopadhyay M, Durazo A, Sohn SH, Strong CD, Gralla EB, Whitelegge JP, Valentine JS. Chattopadhyay M, et al. Among authors: valentine js. Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18663-8. doi: 10.1073/pnas.0807058105. Epub 2008 Nov 20. Proc Natl Acad Sci U S A. 2008. PMID: 19022905 Free PMC article.
148 results