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New Generation of sGC Stimulators: Discovery of Imidazo[1,2-a]pyridine Carboxamide BAY 1165747 (BAY-747), a Long-Acting Soluble Guanylate Cyclase Stimulator for the Treatment of Resistant Hypertension.
Vakalopoulos A, Wunder F, Hartung IV, Redlich G, Jautelat R, Buchgraber P, Hassfeld J, Gromov AV, Lindner N, Bierer D, Gries J, Kroh W, Paulsen H, Mittendorf J, Lang D, Becker-Pelster E, Brockschnieder D, Geiss V, Li V, Straub A, Knorr A, Mondritzki T, Trübel H, Raschke M, Schaefer M, Thomas D, Sandner P, Stasch JP, Follmann M. Vakalopoulos A, et al. J Med Chem. 2023 Jun 8;66(11):7280-7303. doi: 10.1021/acs.jmedchem.2c02082. Epub 2023 Apr 11. J Med Chem. 2023. PMID: 37040336
Identification and characterization of the new generation soluble guanylate cyclase stimulator BAY-747 designed for the treatment of resistant hypertension.
Wunder F, Stasch JP, Knorr A, Mondritzki T, Brockschnieder D, Becker-Pelster EM, Sandner P, Tinel H, Redlich G, Hartung IV, Vakalopoulos A, Follmann M. Wunder F, et al. Among authors: vakalopoulos a. Br J Pharmacol. 2023 Oct;180(19):2500-2513. doi: 10.1111/bph.16142. Epub 2023 Jun 20. Br J Pharmacol. 2023. PMID: 37170767
Prediction of a potentially effective dose in humans for BAY 60-5521, a potent inhibitor of cholesteryl ester transfer protein (CETP) by allometric species scaling and combined pharmacodynamic and physiologically-based pharmacokinetic modelling.
Weber O, Willmann S, Bischoff H, Li V, Vakalopoulos A, Lustig K, Hafner FT, Heinig R, Schmeck C, Buehner K. Weber O, et al. Among authors: vakalopoulos a. Br J Clin Pharmacol. 2012 Feb;73(2):219-31. doi: 10.1111/j.1365-2125.2011.04064.x. Br J Clin Pharmacol. 2012. PMID: 21762205 Free PMC article.
Novel tetrahydrochinoline derived CETP inhibitors.
Schmeck C, Gielen-Haertwig H, Vakalopoulos A, Bischoff H, Li V, Wirtz G, Weber O. Schmeck C, et al. Among authors: vakalopoulos a. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1740-3. doi: 10.1016/j.bmcl.2010.01.071. Epub 2010 Jan 21. Bioorg Med Chem Lett. 2010. PMID: 20137927
Chemically Stabilized DNA Barcodes for DNA-Encoded Chemistry.
Potowski M, Kunig VBK, Eberlein L, Vakalopoulos A, Kast SM, Brunschweiger A. Potowski M, et al. Among authors: vakalopoulos a. Angew Chem Int Ed Engl. 2021 Sep 1;60(36):19744-19749. doi: 10.1002/anie.202104348. Epub 2021 Aug 3. Angew Chem Int Ed Engl. 2021. PMID: 34153170 Free PMC article.
Chromanol derivatives--a novel class of CETP inhibitors.
Vakalopoulos A, Schmeck C, Thutewohl M, Li V, Bischoff H, Lustig K, Weber O, Paulsen H, Elias H. Vakalopoulos A, et al. Bioorg Med Chem Lett. 2011 Jan 1;21(1):488-91. doi: 10.1016/j.bmcl.2010.10.110. Epub 2010 Oct 26. Bioorg Med Chem Lett. 2011. PMID: 21084191
Neladenoson Bialanate Hydrochloride: A Prodrug of a Partial Adenosine A1 Receptor Agonist for the Chronic Treatment of Heart Diseases.
Meibom D, Albrecht-Küpper B, Diedrichs N, Hübsch W, Kast R, Krämer T, Krenz U, Lerchen HG, Mittendorf J, Nell PG, Süssmeier F, Vakalopoulos A, Zimmermann K. Meibom D, et al. Among authors: vakalopoulos a. ChemMedChem. 2017 May 22;12(10):728-737. doi: 10.1002/cmdc.201700151. Epub 2017 May 10. ChemMedChem. 2017. PMID: 28488817
Dibenzodioxocinones--a new class of CETP inhibitors.
Brückner D, Hafner FT, Li V, Schmeck C, Telser J, Vakalopoulos A, Wirtz G. Brückner D, et al. Among authors: vakalopoulos a. Bioorg Med Chem Lett. 2005 Aug 1;15(15):3611-4. doi: 10.1016/j.bmcl.2005.05.073. Bioorg Med Chem Lett. 2005. PMID: 15975789
19 results