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141 results

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Therapeutic targeting Tudor domains in leukemia via CRISPR-Scan Assisted Drug Discovery.
Chan AKN, Han L, Delaney CD, Wang X, Mukhaleva E, Li M, Yang L, Pokharel SP, Mattson N, Garcia M, Wang B, Xu X, Zhang L, Singh P, Elsayed Z, Chen R, Kuang B, Wang J, Yuan YC, Chen B, Chan LN, Rosen ST, Horne D, Müschen M, Chen J, Vaidehi N, Armstrong SA, Su R, Chen CW. Chan AKN, et al. Among authors: vaidehi n. Sci Adv. 2024 Feb 23;10(8):eadk3127. doi: 10.1126/sciadv.adk3127. Epub 2024 Feb 23. Sci Adv. 2024. PMID: 38394203 Free PMC article.
Oligo-PROTAC strategy for cell-selective and targeted degradation of activated STAT3.
Hall J, Zhang Z, Bhattacharya S, Wang D, Alcantara M, Liang Y, Swiderski P, Forman S, Kwak L, Vaidehi N, Kortylewski M. Hall J, et al. Among authors: vaidehi n. Mol Ther Nucleic Acids. 2024 Feb 5;35(1):102137. doi: 10.1016/j.omtn.2024.102137. eCollection 2024 Mar 12. Mol Ther Nucleic Acids. 2024. PMID: 38384444 Free PMC article.
A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens.
Mattson NM, Chan AKN, Miyashita K, Mukhaleva E, Chang WH, Yang L, Ma N, Wang Y, Pokharel SP, Li M, Liu Q, Xu X, Chen R, Singh P, Zhang L, Elsayed Z, Chen B, Keen D, Pirrotte P, Rosen ST, Chen J, LaBarge MA, Shively JE, Vaidehi N, Rockne RC, Feng M, Chen CW. Mattson NM, et al. Among authors: vaidehi n. Nat Struct Mol Biol. 2024 Mar;31(3):465-475. doi: 10.1038/s41594-024-01211-y. Epub 2024 Feb 5. Nat Struct Mol Biol. 2024. PMID: 38316881 Free PMC article.
Molecular annotation of G protein variants in a neurological disorder.
Knight KM, Obarow EG, Wei W, Mani S, Esteller MI, Cui M, Ma N, Martin SA, Brinson E, Hewitt N, Soden GM, Logothetis DE, Vaidehi N, Dohlman HG. Knight KM, et al. Among authors: vaidehi n. Cell Rep. 2023 Dec 26;42(12):113578. doi: 10.1016/j.celrep.2023.113578. Epub 2023 Dec 2. Cell Rep. 2023. PMID: 38043061 Free PMC article. No abstract available.
Engineered odorant receptors illuminate structural principles of odor discrimination.
de March CA, Ma N, Billesbølle CB, Tewari J, Del Torrent CL, van der Velden WJC, Ojiro I, Takayama I, Faust B, Li L, Vaidehi N, Manglik A, Matsunami H. de March CA, et al. Among authors: vaidehi n. bioRxiv [Preprint]. 2023 Nov 17:2023.11.16.567230. doi: 10.1101/2023.11.16.567230. bioRxiv. 2023. PMID: 38014344 Free PMC article. Preprint.
Molecular annotation of G protein variants in a neurological disorder.
Knight KM, Obarow EG, Wei W, Mani S, Esteller MI, Cui M, Ma N, Martin SA, Brinson E, Hewitt N, Soden GM, Logothetis DE, Vaidehi N, Dohlman HG. Knight KM, et al. Among authors: vaidehi n. Cell Rep. 2023 Dec 26;42(12):113462. doi: 10.1016/j.celrep.2023.113462. Epub 2023 Nov 18. Cell Rep. 2023. PMID: 37980565 Free PMC article.
Oligo-PROTAC strategy for cell-selective and targeted degradation of activated STAT3.
Hall J, Zhang Z, Wang D, Bhattacharya S, Alcantara M, Liang Y, Swiderski P, Forman S, Kwak L, Vaidehi N, Kortylewski M. Hall J, et al. Among authors: vaidehi n. bioRxiv [Preprint]. 2023 Aug 3:2023.08.01.551552. doi: 10.1101/2023.08.01.551552. bioRxiv. 2023. PMID: 37577590 Free PMC article. Updated. Preprint.
141 results