Vaid TM - Search Results

1

Identification of small molecule inhibitors against MMP-14 via High-Throughput screening.

Lee H, Youn I, Demissie R, Vaid TM, Che CT, Azar DT, Han KY. Lee H, et al. Among authors: vaid tm. Bioorg Med Chem. 2023 May 1;85:117289. doi: 10.1016/j.bmc.2023.117289. Epub 2023 Apr 17. Bioorg Med Chem. 2023. PMID: 37094433 Free PMC article.

2

Evaluation of interactions between the hepatitis C virus NS3/4A and sulfonamidobenzamide based molecules using molecular docking, molecular dynamics simulations and binding free energy calculations.

Ren J, Vaid TM, Lee H, Ojeda I, Johnson ME. Ren J, et al. Among authors: vaid tm. J Comput Aided Mol Des. 2023 Jan;37(1):53-65. doi: 10.1007/s10822-022-00490-1. Epub 2022 Nov 25. J Comput Aided Mol Des. 2023. PMID: 36427108 Free PMC article.

3

Synergistic Inhibition Guided Fragment-Linking Strategy and Quantitative Structure-Property Relationship Modeling To Design Inhalable Therapeutics for Asthma Targeting CSF1R.

Vaid TM, Demissie R, Kwon Y, Tran T, Moon HG, Villegas JA, Park GY, Johnson ME, Lee H. Vaid TM, et al. ACS Omega. 2023 Jun 1;8(23):20505-20512. doi: 10.1021/acsomega.3c00803. eCollection 2023 Jun 13. ACS Omega. 2023. PMID: 37323402 Free PMC article.

4

Mapping the energy landscape of PROTAC-mediated protein-protein interactions.

Villegas JA, Vaid TM, Johnson ME, Moore TW. Villegas JA, et al. Among authors: vaid tm. Comput Struct Biotechnol J. 2023 Mar 2;21:1885-1892. doi: 10.1016/j.csbj.2023.02.049. eCollection 2023. Comput Struct Biotechnol J. 2023. PMID: 36923472 Free PMC article.

5

Identification of a Novel Subtype-Selective α_1B-Adrenoceptor Antagonist.

Abdul-Ridha A, de Zhang LA, Betrie AH, Deluigi M, Vaid TM, Whitehead A, Zhang Y, Davis B, Harris R, Simmonite H, Hubbard RE, Gooley PR, Plückthun A, Bathgate RAD, Chalmers DK, Scott DJ. Abdul-Ridha A, et al. Among authors: vaid tm. ACS Chem Neurosci. 2024 Feb 7;15(3):671-684. doi: 10.1021/acschemneuro.3c00767. Epub 2024 Jan 18. ACS Chem Neurosci. 2024. PMID: 38238043

6

Crystal structure of the α_1B-adrenergic receptor reveals molecular determinants of selective ligand recognition.

Deluigi M, Morstein L, Schuster M, Klenk C, Merklinger L, Cridge RR, de Zhang LA, Klipp A, Vacca S, Vaid TM, Mittl PRE, Egloff P, Eberle SA, Zerbe O, Chalmers DK, Scott DJ, Plückthun A. Deluigi M, et al. Among authors: vaid tm. Nat Commun. 2022 Jan 19;13(1):382. doi: 10.1038/s41467-021-27911-3. Nat Commun. 2022. PMID: 35046410 Free PMC article.

7

Conformational Changes in Tyrosine 11 of Neurotensin Are Required to Activate the Neurotensin Receptor 1.

Bumbak F, Thomas T, Noonan-Williams BJ, Vaid TM, Yan F, Whitehead AR, Bruell S, Kocan M, Tan X, Johnson MA, Bathgate RAD, Chalmers DK, Gooley PR, Scott DJ. Bumbak F, et al. Among authors: vaid tm. ACS Pharmacol Transl Sci. 2020 Apr 29;3(4):690-705. doi: 10.1021/acsptsci.0c00026. eCollection 2020 Aug 14. ACS Pharmacol Transl Sci. 2020. PMID: 32832871 Free PMC article.

8

Probing the correlation between ligand efficacy and conformational diversity at the α_1A-adrenoreceptor reveals allosteric coupling of its microswitches.

Wu FJ, Williams LM, Abdul-Ridha A, Gunatilaka A, Vaid TM, Kocan M, Whitehead AR, Griffin MDW, Bathgate RAD, Scott DJ, Gooley PR. Wu FJ, et al. Among authors: vaid tm. J Biol Chem. 2020 May 22;295(21):7404-7417. doi: 10.1074/jbc.RA120.012842. Epub 2020 Apr 17. J Biol Chem. 2020. PMID: 32303636 Free PMC article.

9

INPHARMA-Based Determination of Ligand Binding Modes at α₁ -Adrenergic Receptors Explains the Molecular Basis of Subtype Selectivity.

Vaid TM, Chalmers DK, Scott DJ, Gooley PR. Vaid TM, et al. Chemistry. 2020 Sep 10;26(51):11796-11805. doi: 10.1002/chem.202000642. Epub 2020 Aug 18. Chemistry. 2020. PMID: 32291801

10

Diazepam is not a direct allosteric modulator of α₁-adrenoceptors, but modulates receptor signaling by inhibiting phosphodiesterase-4.

Williams LM, He X, Vaid TM, Abdul-Ridha A, Whitehead AR, Gooley PR, Bathgate RAD, Williams SJ, Scott DJ. Williams LM, et al. Among authors: vaid tm. Pharmacol Res Perspect. 2018 Dec 26;7(1):e00455. doi: 10.1002/prp2.455. eCollection 2019 Feb. Pharmacol Res Perspect. 2018. PMID: 30619611 Free PMC article.

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