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Impaired circulating myeloid CD1c+ dendritic cell function in human glioblastoma is restored by p38 inhibition - implications for the next generation of DC vaccines.
Adhikaree J, Franks HA, Televantos C, Vaghela P, Kaur AP, Walker D, Schmitz M, Jackson AM, Patel PM. Adhikaree J, et al. Among authors: vaghela p. Oncoimmunology. 2019 Apr 13;8(7):1593803. doi: 10.1080/2162402X.2019.1593803. eCollection 2019. Oncoimmunology. 2019. PMID: 31143512 Free PMC article.
T cell repertoire to citrullinated self-peptides in healthy humans is not confined to the HLA-DR SE alleles; Targeting of citrullinated self-peptides presented by HLA-DP4 for tumour therapy.
Brentville VA, Symonds P, Cook KW, Daniels I, Pitt T, Gijon M, Vaghela P, Xue W, Shah S, Metheringham RL, Durrant LG. Brentville VA, et al. Among authors: vaghela p. Oncoimmunology. 2019 Feb 20;8(5):e1576490. doi: 10.1080/2162402X.2019.1576490. eCollection 2019. Oncoimmunology. 2019. PMID: 31069134 Free PMC article.
Combination vaccine based on citrullinated vimentin and enolase peptides induces potent CD4-mediated anti-tumor responses.
Brentville VA, Metheringham RL, Daniels I, Atabani S, Symonds P, Cook KW, Vankemmelbeke M, Choudhury R, Vaghela P, Gijon M, Meiners G, Krebber WJ, Melief CJM, Durrant LG. Brentville VA, et al. Among authors: vaghela p. J Immunother Cancer. 2020 Jun;8(1):e000560. doi: 10.1136/jitc-2020-000560. J Immunother Cancer. 2020. PMID: 32561639 Free PMC article.
Homocitrullination of lysine residues mediated by myeloid-derived suppressor cells in the tumor environment is a target for cancer immunotherapy.
Cook KW, Xue W, Symonds P, Daniels I, Gijon M, Boocock D, Coveney C, Miles AK, Shah S, Atabani S, Choudhury RH, Vaghela P, Weston D, Metheringham RL, Brentville VA, Durrant LG. Cook KW, et al. Among authors: vaghela p. J Immunother Cancer. 2021 Jul;9(7):e001910. doi: 10.1136/jitc-2020-001910. J Immunother Cancer. 2021. PMID: 34321274 Free PMC article.
Citrullinated glucose-regulated protein 78 is a candidate target for melanoma immunotherapy.
Brentville VA, Symonds P, Chua J, Skinner A, Daniels I, Cook KW, Koncarevic S, Martinez-Pinna R, Shah S, Choudhury RH, Vaghela P, Weston D, Al-Omari A, Davis J, Durrant LG. Brentville VA, et al. Among authors: vaghela p. Front Immunol. 2022 Dec 5;13:1066185. doi: 10.3389/fimmu.2022.1066185. eCollection 2022. Front Immunol. 2022. PMID: 36544781 Free PMC article.
Immune responses to citrullinated and homocitrullinated peptides in healthy donors are not restricted to the HLA SE shared allele and can be selected into the memory pool.
Choudhury RH, Daniels I, Vaghela P, Atabani S, Kirk T, Symonds P, Cook KW, Al-Omari A, Weston D, Shah S, Hutchinson D, Paston SJ, Metheringham RL, Brentville VA, Durrant LG. Choudhury RH, et al. Among authors: vaghela p. Immunology. 2023 Aug;169(4):467-486. doi: 10.1111/imm.13645. Epub 2023 Apr 13. Immunology. 2023. PMID: 37055914
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