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Limitations of Dual-Single Guide RNA CRISPR Strategies for the Treatment of Central Nervous System Genetic Disorders.
Hum Gene Ther. 2023 Sep;34(17-18):958-974. doi: 10.1089/hum.2023.109.
Hum Gene Ther. 2023.
PMID: 37658843
Review.
CRISPR/Cas9-Mediated Genome Editing for Huntington's Disease.
Vachey G, Déglon N.
Vachey G, et al.
Methods Mol Biol. 2018;1780:463-481. doi: 10.1007/978-1-4939-7825-0_21.
Methods Mol Biol. 2018.
PMID: 29856031
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The Self-Inactivating KamiCas9 System for the Editing of CNS Disease Genes.
Merienne N, Vachey G, de Longprez L, Meunier C, Zimmer V, Perriard G, Canales M, Mathias A, Herrgott L, Beltraminelli T, Maulet A, Dequesne T, Pythoud C, Rey M, Pellerin L, Brouillet E, Perrier AL, du Pasquier R, Déglon N.
Merienne N, et al. Among authors: vachey g.
Cell Rep. 2017 Sep 19;20(12):2980-2991. doi: 10.1016/j.celrep.2017.08.075.
Cell Rep. 2017.
PMID: 28930690
Free article.
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Scalable Production of AAV Vectors in Orbitally Shaken HEK293 Cells.
Blessing D, Vachey G, Pythoud C, Rey M, Padrun V, Wurm FM, Schneider BL, Déglon N.
Blessing D, et al. Among authors: vachey g.
Mol Ther Methods Clin Dev. 2018 Nov 22;13:14-26. doi: 10.1016/j.omtm.2018.11.004. eCollection 2019 Jun 14.
Mol Ther Methods Clin Dev. 2018.
PMID: 30591923
Free PMC article.
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Therapeutic efficacy of regulable GDNF expression for Huntington's and Parkinson's disease by a high-induction, background-free "GeneSwitch" vector.
Cheng S, Tereshchenko J, Zimmer V, Vachey G, Pythoud C, Rey M, Liefhebber J, Raina A, Streit F, Mazur A, Bähr M, Konstantinova P, Déglon N, Kügler S.
Cheng S, et al. Among authors: vachey g.
Exp Neurol. 2018 Nov;309:79-90. doi: 10.1016/j.expneurol.2018.07.017. Epub 2018 Aug 1.
Exp Neurol. 2018.
PMID: 30076831
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Revisiting the outcome of adult wild-type Htt inactivation in the context of HTT-lowering strategies for Huntington's disease.
Regio S, Vachey G, Goñi E, Duarte F, Rybarikova M, Sipion M, Rey M, Huarte M, Déglon N.
Regio S, et al. Among authors: vachey g.
Brain Commun. 2023 Dec 7;5(6):fcad344. doi: 10.1093/braincomms/fcad344. eCollection 2023.
Brain Commun. 2023.
PMID: 38116140
Free PMC article.
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