Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

Search Results

28 results

Filters applied: . Clear all
Results are displayed in a computed author sort order. The Results By Year timeline is not available.
Page 1
High-throughput purification platform in support of drug discovery.
Liu M, Chen K, Christian D, Fatima T, Pissarnitski N, Streckfuss E, Zhang C, Xia L, Borges S, Shi Z, Vachal P, Tata J, Athanasopoulos J. Liu M, et al. Among authors: vachal p. ACS Comb Sci. 2012 Jan 9;14(1):51-9. doi: 10.1021/co200138h. Epub 2011 Nov 2. ACS Comb Sci. 2012. PMID: 22032344
Organic chemistry. Nanomole-scale high-throughput chemistry for the synthesis of complex molecules.
Buitrago Santanilla A, Regalado EL, Pereira T, Shevlin M, Bateman K, Campeau LC, Schneeweis J, Berritt S, Shi ZC, Nantermet P, Liu Y, Helmy R, Welch CJ, Vachal P, Davies IW, Cernak T, Dreher SD. Buitrago Santanilla A, et al. Among authors: vachal p. Science. 2015 Jan 2;347(6217):49-53. doi: 10.1126/science.1259203. Epub 2014 Nov 20. Science. 2015. PMID: 25554781
Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1H-benzimidazole Diacylglycerol Acyltransferase 1 Inhibitors.
Cernak T, Gesmundo NJ, Dykstra K, Yu Y, Wu Z, Shi ZC, Vachal P, Sperbeck D, He S, Murphy BA, Sonatore L, Williams S, Madeira M, Verras A, Reiter M, Lee CH, Cuff J, Sherer EC, Kuethe J, Goble S, Perrotto N, Pinto S, Shen DM, Nargund R, Balkovec J, DeVita RJ, Dreher SD. Cernak T, et al. Among authors: vachal p. J Med Chem. 2017 May 11;60(9):3594-3605. doi: 10.1021/acs.jmedchem.6b01543. Epub 2017 Mar 2. J Med Chem. 2017. PMID: 28252959
Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC).
Yu Y, Wu Z, Shi ZC, He S, Lai Z, Cernak TA, Vachal P, Liu M, Liu J, Hong Q, Jian T, Guiadeen D, Krikorian A, Sperbeck DM, Verras A, Sonatore LM, Murphy BA, Wiltsie J, Chung CC, Gorski JN, Liu J, Xiao J, Wolff M, Tong SX, Madeira M, Karanam BV, Shen DM, Balkovec JM, De Vita RJ, Pinto S, Nargund RP. Yu Y, et al. Among authors: vachal p. Bioorg Med Chem Lett. 2019 Jun 1;29(11):1380-1385. doi: 10.1016/j.bmcl.2019.03.039. Epub 2019 Mar 27. Bioorg Med Chem Lett. 2019. PMID: 30952592
Synthesis of HDAC Inhibitor Libraries via Microscale Workflow.
Dykstra KD, Streckfuss E, Liu M, Liu J, Yu Y, Wang M, Kozlowski JA, Myers RW, Buevich AV, Maletic MM, Vachal P, Krska SW. Dykstra KD, et al. Among authors: vachal p. ACS Med Chem Lett. 2021 Feb 8;12(3):337-342. doi: 10.1021/acsmedchemlett.0c00596. eCollection 2021 Mar 11. ACS Med Chem Lett. 2021. PMID: 33738059 Free PMC article.
28 results