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Characterization of antibiotic resistomes by reprogrammed bacteriophage-enabled functional metagenomics in clinical strains.
Apjok G, Számel M, Christodoulou C, Seregi V, Vásárhelyi BM, Stirling T, Eszenyi B, Sári T, Vidovics F, Nagrand E, Kovács D, Szili P, Lantos II, Méhi O, Jangir PK, Herczeg R, Gálik B, Urbán P, Gyenesei A, Draskovits G, Nyerges Á, Fekete G, Bodai L, Zsindely N, Dénes B, Yosef I, Qimron U, Papp B, Pál C, Kintses B. Apjok G, et al. Among authors: vasarhelyi bm. Nat Microbiol. 2023 Mar;8(3):410-423. doi: 10.1038/s41564-023-01320-2. Epub 2023 Feb 9. Nat Microbiol. 2023. PMID: 36759752 Free PMC article.
Directed evolution of multiple genomic loci allows the prediction of antibiotic resistance.
Nyerges Á, Csörgő B, Draskovits G, Kintses B, Szili P, Ferenc G, Révész T, Ari E, Nagy I, Bálint B, Vásárhelyi BM, Bihari P, Számel M, Balogh D, Papp H, Kalapis D, Papp B, Pál C. Nyerges Á, et al. Among authors: vasarhelyi bm. Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):E5726-E5735. doi: 10.1073/pnas.1801646115. Epub 2018 Jun 5. Proc Natl Acad Sci U S A. 2018. PMID: 29871954 Free PMC article.
Phylogenetic barriers to horizontal transfer of antimicrobial peptide resistance genes in the human gut microbiota.
Kintses B, Méhi O, Ari E, Számel M, Györkei Á, Jangir PK, Nagy I, Pál F, Fekete G, Tengölics R, Nyerges Á, Likó I, Bálint A, Molnár T, Bálint B, Vásárhelyi BM, Bustamante M, Papp B, Pál C. Kintses B, et al. Among authors: vasarhelyi bm. Nat Microbiol. 2019 Mar;4(3):447-458. doi: 10.1038/s41564-018-0313-5. Epub 2018 Dec 17. Nat Microbiol. 2019. PMID: 30559406 Free PMC article.
Rapid Evolution of Reduced Susceptibility against a Balanced Dual-Targeting Antibiotic through Stepping-Stone Mutations.
Szili P, Draskovits G, Révész T, Bogár F, Balogh D, Martinek T, Daruka L, Spohn R, Vásárhelyi BM, Czikkely M, Kintses B, Grézal G, Ferenc G, Pál C, Nyerges Á. Szili P, et al. Among authors: vasarhelyi bm. Antimicrob Agents Chemother. 2019 Aug 23;63(9):e00207-19. doi: 10.1128/AAC.00207-19. Print 2019 Sep. Antimicrob Agents Chemother. 2019. PMID: 31235632 Free PMC article.
Rational design of balanced dual-targeting antibiotics with limited resistance.
Nyerges A, Tomašič T, Durcik M, Revesz T, Szili P, Draskovits G, Bogar F, Skok Ž, Zidar N, Ilaš J, Zega A, Kikelj D, Daruka L, Kintses B, Vasarhelyi B, Foldesi I, Kata D, Welin M, Kimbung R, Focht D, Mašič LP, Pal C. Nyerges A, et al. PLoS Biol. 2020 Oct 5;18(10):e3000819. doi: 10.1371/journal.pbio.3000819. eCollection 2020 Oct. PLoS Biol. 2020. PMID: 33017402 Free PMC article.
Functional Anatomical Changes in Ulcerative Colitis Patients Determine Their Gut Microbiota Composition and Consequently the Possible Treatment Outcome.
Bálint A, Farkas K, Méhi O, Kintses B, Vásárhelyi BM, Ari E, Pál C, Madácsy T, Maléth J, Szántó KJ, Nagy I, Rutka M, Bacsur P, Szűcs D, Szepes Z, Nagy F, Fábián A, Bor R, Milassin Á, Molnár T. Bálint A, et al. Among authors: vasarhelyi bm. Pharmaceuticals (Basel). 2020 Oct 28;13(11):346. doi: 10.3390/ph13110346. Pharmaceuticals (Basel). 2020. PMID: 33126430 Free PMC article.
Prolonged activity of the transposase helper may raise safety concerns during DNA transposon-based gene therapy.
Imre G, Takács B, Czipa E, Drubi AB, Jaksa G, Latinovics D, Nagy A, Karkas R, Hudoba L, Vásárhelyi BM, Pankotai-Bodó G, Blastyák A, Hegedűs Z, Germán P, Bálint B, Ahmed Abdullah KS, Kopasz AG, Kovács A, Nagy LG, Sükösd F, Pintér L, Rülicke T, Barta E, Nagy I, Haracska L, Mátés L. Imre G, et al. Among authors: vasarhelyi bm. Mol Ther Methods Clin Dev. 2023 Mar 14;29:145-159. doi: 10.1016/j.omtm.2023.03.003. eCollection 2023 Jun 8. Mol Ther Methods Clin Dev. 2023. PMID: 37025950 Free PMC article.
The complete genome sequence of Ensifer meliloti strain CCMM B554 (FSM-MA), a highly effective nitrogen-fixing microsymbiont of Medicago truncatula Gaertn.
Nagymihály M, Vásarhelyi BM, Barrière Q, Chong TM, Bálint B, Bihari P, Hong KW, Horváth B, Ibijbijen J, Amar M, Farkas A, Kondorosi É, Chan KG, Gruber V, Ratet P, Mergaert P, Kereszt A. Nagymihály M, et al. Among authors: vasarhelyi bm. Stand Genomic Sci. 2017 Dec 13;12:75. doi: 10.1186/s40793-017-0298-3. eCollection 2017. Stand Genomic Sci. 2017. PMID: 29255570 Free PMC article.