Uwamizu A - Search Results

1

Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques.

Nagatake T, Kishino S, Urano E, Murakami H, Kitamura N, Konishi K, Ohno H, Tiwari P, Morimoto S, Node E, Adachi J, Abe Y, Isoyama J, Sawane K, Honda T, Inoue A, Uwamizu A, Matsuzaka T, Miyamoto Y, Hirata SI, Saika A, Shibata Y, Hosomi K, Matsunaga A, Shimano H, Arita M, Aoki J, Oka M, Matsutani A, Tomonaga T, Kabashima K, Miyachi M, Yasutomi Y, Ogawa J, Kunisawa J. Nagatake T, et al. Among authors: uwamizu a. Mucosal Immunol. 2022 Feb;15(2):289-300. doi: 10.1038/s41385-021-00477-5. Epub 2022 Jan 10. Mucosal Immunol. 2022. PMID: 35013573 Free PMC article.

2

Novel lysophosphoplipid receptors: their structure and function.

Makide K, Uwamizu A, Shinjo Y, Ishiguro J, Okutani M, Inoue A, Aoki J. Makide K, et al. Among authors: uwamizu a. J Lipid Res. 2014 Oct;55(10):1986-95. doi: 10.1194/jlr.R046920. Epub 2014 Jun 2. J Lipid Res. 2014. PMID: 24891334 Free PMC article. Review.

3

Lysophosphatidylserine analogues differentially activate three LysoPS receptors.

Uwamizu A, Inoue A, Suzuki K, Okudaira M, Shuto A, Shinjo Y, Ishiguro J, Makide K, Ikubo M, Nakamura S, Jung S, Sayama M, Otani Y, Ohwada T, Aoki J. Uwamizu A, et al. J Biochem. 2015 Mar;157(3):151-60. doi: 10.1093/jb/mvu060. Epub 2014 Oct 14. J Biochem. 2015. PMID: 25320102

4

Structure-activity relationships of lysophosphatidylserine analogs as agonists of G-protein-coupled receptors GPR34, P2Y10, and GPR174.

Ikubo M, Inoue A, Nakamura S, Jung S, Sayama M, Otani Y, Uwamizu A, Suzuki K, Kishi T, Shuto A, Ishiguro J, Okudaira M, Kano K, Makide K, Aoki J, Ohwada T. Ikubo M, et al. Among authors: uwamizu a. J Med Chem. 2015 May 28;58(10):4204-19. doi: 10.1021/jm5020082. Epub 2015 May 13. J Med Chem. 2015. PMID: 25970039

5

Conformational Constraint of the Glycerol Moiety of Lysophosphatidylserine Affords Compounds with Receptor Subtype Selectivity.

Jung S, Inoue A, Nakamura S, Kishi T, Uwamizu A, Sayama M, Ikubo M, Otani Y, Kano K, Makide K, Aoki J, Ohwada T. Jung S, et al. Among authors: uwamizu a. J Med Chem. 2016 Apr 28;59(8):3750-76. doi: 10.1021/acs.jmedchem.5b01925. Epub 2016 Apr 14. J Med Chem. 2016. PMID: 27077565

6

Probing the Hydrophobic Binding Pocket of G-Protein-Coupled Lysophosphatidylserine Receptor GPR34/LPS₁ by Docking-Aided Structure-Activity Analysis.

Sayama M, Inoue A, Nakamura S, Jung S, Ikubo M, Otani Y, Uwamizu A, Kishi T, Makide K, Aoki J, Hirokawa T, Ohwada T. Sayama M, et al. Among authors: uwamizu a. J Med Chem. 2017 Jul 27;60(14):6384-6399. doi: 10.1021/acs.jmedchem.7b00693. Epub 2017 Jul 17. J Med Chem. 2017. PMID: 28715213

7

Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA₆.

Taniguchi R, Inoue A, Sayama M, Uwamizu A, Yamashita K, Hirata K, Yoshida M, Tanaka Y, Kato HE, Nakada-Nakura Y, Otani Y, Nishizawa T, Doi T, Ohwada T, Ishitani R, Aoki J, Nureki O. Taniguchi R, et al. Among authors: uwamizu a. Nature. 2017 Aug 17;548(7667):356-360. doi: 10.1038/nature23448. Epub 2017 Aug 9. Nature. 2017. PMID: 28792932

8

Membrane Phospholipid Analogues as Molecular Rulers to Probe the Position of the Hydrophobic Contact Point of Lysophospholipid Ligands on the Surface of G-Protein-Coupled Receptor during Membrane Approach.

Sayama M, Uwamizu A, Otani Y, Inoue A, Aoki J, Sekijima M, Ohwada T. Sayama M, et al. Among authors: uwamizu a. Biochemistry. 2020 Mar 24;59(11):1173-1201. doi: 10.1021/acs.biochem.0c00061. Epub 2020 Mar 10. Biochemistry. 2020. PMID: 32124599

9

Non-naturally Occurring Regio Isomer of Lysophosphatidylserine Exhibits Potent Agonistic Activity toward G Protein-Coupled Receptors.

Nakamura S, Sayama M, Uwamizu A, Jung S, Ikubo M, Otani Y, Kano K, Omi J, Inoue A, Aoki J, Ohwada T. Nakamura S, et al. Among authors: uwamizu a. J Med Chem. 2020 Sep 10;63(17):9990-10029. doi: 10.1021/acs.jmedchem.0c01126. Epub 2020 Aug 24. J Med Chem. 2020. PMID: 32787112

10

Switching Lysophosphatidylserine G Protein-Coupled Receptor Agonists to Antagonists by Acylation of the Hydrophilic Serine Amine.

Sayama M, Uwamizu A, Ikubo M, Chen L, Yan G, Otani Y, Inoue A, Aoki J, Ohwada T. Sayama M, et al. Among authors: uwamizu a. J Med Chem. 2021 Jul 22;64(14):10059-10101. doi: 10.1021/acs.jmedchem.1c00347. Epub 2021 Jul 7. J Med Chem. 2021. PMID: 34233115

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