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Congenital anemia reveals distinct targeting mechanisms for master transcription factor GATA1.
Ludwig LS, Lareau CA, Bao EL, Liu N, Utsugisawa T, Tseng AM, Myers SA, Verboon JM, Ulirsch JC, Luo W, Muus C, Fiorini C, Olive ME, Vockley CM, Munschauer M, Hunter A, Ogura H, Yamamoto T, Inada H, Nakagawa S, Ohzono S, Subramanian V, Chiarle R, Glader B, Carr SA, Aryee MJ, Kundaje A, Orkin SH, Regev A, McCavit TL, Kanno H, Sankaran VG. Ludwig LS, et al. Among authors: utsugisawa t. Blood. 2022 Apr 21;139(16):2534-2546. doi: 10.1182/blood.2021013753. Blood. 2022. PMID: 35030251 Free PMC article.
Erythrocyte glutathione is a novel biomarker of Diamond-Blackfan anemia.
Utsugisawa T, Uchiyama T, Toki T, Ogura H, Aoki T, Hamaguchi I, Ishiguro A, Ohara A, Kojima S, Ohga S, Ito E, Kanno H. Utsugisawa T, et al. Blood Cells Mol Dis. 2016 Jul;59:31-6. doi: 10.1016/j.bcmd.2016.03.007. Epub 2016 Apr 11. Blood Cells Mol Dis. 2016. PMID: 27282564
KLF1 mutation E325K induces cell cycle arrest in erythroid cells differentiated from congenital dyserythropoietic anemia patient-specific induced pluripotent stem cells.
Kohara H, Utsugisawa T, Sakamoto C, Hirose L, Ogawa Y, Ogura H, Sugawara A, Liao J, Aoki T, Iwasaki T, Asai T, Doisaki S, Okuno Y, Muramatsu H, Abe T, Kurita R, Miyamoto S, Sakuma T, Shiba M, Yamamoto T, Ohga S, Yoshida K, Ogawa S, Ito E, Kojima S, Kanno H, Tani K. Kohara H, et al. Among authors: utsugisawa t. Exp Hematol. 2019 May;73:25-37.e8. doi: 10.1016/j.exphem.2019.03.001. Epub 2019 Mar 12. Exp Hematol. 2019. PMID: 30876823 Free article. Clinical Trial.
Deficiency of ribosomal protein S19 in CD34+ cells generated by siRNA blocks erythroid development and mimics defects seen in Diamond-Blackfan anemia.
Flygare J, Kiefer T, Miyake K, Utsugisawa T, Hamaguchi I, Da Costa L, Richter J, Davey EJ, Matsson H, Dahl N, Wiznerowicz M, Trono D, Karlsson S. Flygare J, et al. Among authors: utsugisawa t. Blood. 2005 Jun 15;105(12):4627-34. doi: 10.1182/blood-2004-08-3115. Epub 2004 Dec 30. Blood. 2005. PMID: 15626736 Free article.
42 results