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Dimebon slows progression of proteinopathy in γ-synuclein transgenic mice.
Bachurin SO, Shelkovnikova TA, Ustyugov AA, Peters O, Khritankova I, Afanasieva MA, Tarasova TV, Alentov II, Buchman VL, Ninkina NN. Bachurin SO, et al. Among authors: ustyugov aa. Neurotox Res. 2012 Jul;22(1):33-42. doi: 10.1007/s12640-011-9299-y. Epub 2011 Dec 17. Neurotox Res. 2012. PMID: 22179976 Free PMC article.
Dimebon does not ameliorate pathological changes caused by expression of truncated (1-120) human alpha-synuclein in dopaminergic neurons of transgenic mice.
Shelkovnikova TA, Ustyugov AA, Millership S, Peters O, Anichtchik O, Spillantini MG, Buchman VL, Bachurin SO, Ninkina NN. Shelkovnikova TA, et al. Among authors: ustyugov aa. Neurodegener Dis. 2011;8(6):430-7. doi: 10.1159/000324989. Epub 2011 May 12. Neurodegener Dis. 2011. PMID: 21576917 Free PMC article.
Fused in sarcoma (FUS) protein lacking nuclear localization signal (NLS) and major RNA binding motifs triggers proteinopathy and severe motor phenotype in transgenic mice.
Shelkovnikova TA, Peters OM, Deykin AV, Connor-Robson N, Robinson H, Ustyugov AA, Bachurin SO, Ermolkevich TG, Goldman IL, Sadchikova ER, Kovrazhkina EA, Skvortsova VI, Ling SC, Da Cruz S, Parone PA, Buchman VL, Ninkina NN. Shelkovnikova TA, et al. Among authors: ustyugov aa. J Biol Chem. 2013 Aug 30;288(35):25266-25274. doi: 10.1074/jbc.M113.492017. Epub 2013 Jul 18. J Biol Chem. 2013. PMID: 23867462 Free PMC article.
Early lethality and neuronal proteinopathy in mice expressing cytoplasm-targeted FUS that lacks the RNA recognition motif.
Robinson HK, Deykin AV, Bronovitsky EV, Ovchinnikov RK, Ustyugov AA, Shelkovnikova TA, Kukharsky MS, Ermolkevich TG, Goldman IL, Sadchikova ER, Kovrazhkina EA, Bachurin SO, Buchman VL, Ninkina NN. Robinson HK, et al. Among authors: ustyugov aa. Amyotroph Lateral Scler Frontotemporal Degener. 2015;16(5-6):402-9. doi: 10.3109/21678421.2015.1040994. Epub 2015 May 20. Amyotroph Lateral Scler Frontotemporal Degener. 2015. PMID: 25991062 Free PMC article.
C9ORF72 hexanucleotide repeat expansion in ALS patients from the Central European Russia population.
Abramycheva NY, Lysogorskaia EV, Stepanova MS, Zakharova MN, Kovrazhkina EA, Razinskaya OD, Smirnov AP, Maltsev AV, Ustyugov AA, Kukharsky MS, Khritankova IV, Bachurin SO, Cooper-Knock J, Buchman VL, Illarioshkin SN, Skvortsova VI, Ninkina N. Abramycheva NY, et al. Among authors: ustyugov aa. Neurobiol Aging. 2015 Oct;36(10):2908.e5-9. doi: 10.1016/j.neurobiolaging.2015.07.004. Epub 2015 Jul 9. Neurobiol Aging. 2015. PMID: 26254955
9-Substituted acridine derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors possessing antioxidant activity for Alzheimer's disease treatment.
Makhaeva GF, Lushchekina SV, Boltneva NP, Serebryakova OG, Rudakova EV, Ustyugov AA, Bachurin SO, Shchepochkin AV, Chupakhin ON, Charushin VN, Richardson RJ. Makhaeva GF, et al. Among authors: ustyugov aa. Bioorg Med Chem. 2017 Nov 1;25(21):5981-5994. doi: 10.1016/j.bmc.2017.09.028. Epub 2017 Sep 20. Bioorg Med Chem. 2017. PMID: 28986116
49 results