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Page 1
Discovery of Novel Pyrazole-Based Selective Aldosterone Synthase (CYP11B2) Inhibitors: A New Template to Coordinate the Heme-Iron Motif of CYP11B2.
Sakakibara R, Sasaki W, Onda Y, Yamaguchi M, Ushirogochi H, Hiraga Y, Sato K, Nishio M, Egi Y, Takedomi K, Shimizu H, Ohbora T, Akahoshi F. Sakakibara R, et al. Among authors: ushirogochi h. J Med Chem. 2018 Jul 12;61(13):5594-5608. doi: 10.1021/acs.jmedchem.8b00328. Epub 2018 Jun 22. J Med Chem. 2018. PMID: 29878770
5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of beta-lactamases.
Venkatesan AM, Agarwal A, Abe T, Ushirogochi H, Ado M, Tsuyoshi T, Dos Santos O, Li Z, Francisco G, Lin YI, Petersen PJ, Yang Y, Weiss WJ, Shlaes DM, Mansour TS. Venkatesan AM, et al. Among authors: ushirogochi h. Bioorg Med Chem. 2008 Feb 15;16(4):1890-902. doi: 10.1016/j.bmc.2007.11.006. Epub 2007 Nov 5. Bioorg Med Chem. 2008. PMID: 18061461
Structure-activity relationship of 6-methylidene penems bearing 6,5 bicyclic heterocycles as broad-spectrum beta-lactamase inhibitors: evidence for 1,4-thiazepine intermediates with C7 R stereochemistry by computational methods.
Venkatesan AM, Agarwal A, Abe T, Ushirogochi H, Yamamura I, Ado M, Tsuyoshi T, Dos Santos O, Gu Y, Sum FW, Li Z, Francisco G, Lin YI, Petersen PJ, Yang Y, Kumagai T, Weiss WJ, Shlaes DM, Knox JR, Mansour TS. Venkatesan AM, et al. Among authors: ushirogochi h. J Med Chem. 2006 Jul 27;49(15):4623-37. doi: 10.1021/jm060021p. J Med Chem. 2006. PMID: 16854068
In vitro and in vivo activities of novel 6-methylidene penems as beta-lactamase inhibitors.
Weiss WJ, Petersen PJ, Murphy TM, Tardio L, Yang Y, Bradford PA, Venkatesan AM, Abe T, Isoda T, Mihira A, Ushirogochi H, Takasake T, Projan S, O'Connell J, Mansour TS. Weiss WJ, et al. Among authors: ushirogochi h. Antimicrob Agents Chemother. 2004 Dec;48(12):4589-96. doi: 10.1128/AAC.48.12.4589-4596.2004. Antimicrob Agents Chemother. 2004. PMID: 15561830 Free PMC article.
On the absolute configuration in 1,4-dihydrothiazepine covalent complexes derived from inhibition of class A and C beta-lactamases with 6-methylidene penems.
Mansour TS, Agarwal A, Venkatesan A, Abe T, Mihira A, Takasaki T, Sato K, Ushirogochi H, Yamamura I, Isoda T, Li Z, Yang Y, Kumagai T. Mansour TS, et al. Among authors: ushirogochi h. ChemMedChem. 2007 Dec;2(12):1713-6. doi: 10.1002/cmdc.200700144. ChemMedChem. 2007. PMID: 17868160 No abstract available.
A novel, mild, and facile method to prepare 6-methylidene penem derivatives.
Abe T, Sato C, Ushirogochi H, Sato K, Takasaki T, Isoda T, Mihira A, Yamamura I, Hayashi K, Kumagai T, Tamai S, Shiro M, Venkatesan AM, Mansour TS. Abe T, et al. Among authors: ushirogochi h. J Org Chem. 2004 Sep 3;69(18):5850-60. doi: 10.1021/jo049880g. J Org Chem. 2004. PMID: 15373470