Urtti A - Search Results

1

Understanding Molecular Drivers of Melanin Binding To Support Rational Design of Small Molecule Ophthalmic Drugs.

Jakubiak P, Reutlinger M, Mattei P, Schuler F, Urtti A, Alvarez-Sánchez R. Jakubiak P, et al. Among authors: urtti a. J Med Chem. 2018 Nov 21;61(22):10106-10115. doi: 10.1021/acs.jmedchem.8b01281. Epub 2018 Nov 13. J Med Chem. 2018. PMID: 30398862

2

Computational prediction of oral drug absorption based on absorption rate constants in humans.

Linnankoski J, Mäkelä JM, Ranta VP, Urtti A, Yliperttula M. Linnankoski J, et al. Among authors: urtti a. J Med Chem. 2006 Jun 15;49(12):3674-81. doi: 10.1021/jm051231p. J Med Chem. 2006. PMID: 16759110

3

Exploring the structure-activity relationships of ABCC2 modulators using a screening approach.

Wissel G, Kudryavtsev P, Ghemtio L, Tammela P, Wipf P, Yliperttula M, Finel M, Urtti A, Kidron H, Xhaard H. Wissel G, et al. Among authors: urtti a. Bioorg Med Chem. 2015 Jul 1;23(13):3513-25. doi: 10.1016/j.bmc.2015.04.029. Epub 2015 Apr 17. Bioorg Med Chem. 2015. PMID: 25935289 Free PMC article.

4

Interpretation of Ocular Melanin Drug Binding Assays. Alternatives to the Model of Multiple Classes of Independent Sites.

Manzanares JA, Rimpelä AK, Urtti A. Manzanares JA, et al. Among authors: urtti a. Mol Pharm. 2016 Apr 4;13(4):1251-7. doi: 10.1021/acs.molpharmaceut.5b00783. Epub 2016 Feb 5. Mol Pharm. 2016. PMID: 26820602

5

Melanin binding study of clinical drugs with cassette dosing and rapid equilibrium dialysis inserts.

Pelkonen L, Tengvall-Unadike U, Ruponen M, Kidron H, Del Amo EM, Reinisalo M, Urtti A. Pelkonen L, et al. Among authors: urtti a. Eur J Pharm Sci. 2017 Nov 15;109:162-168. doi: 10.1016/j.ejps.2017.07.027. Epub 2017 Jul 27. Eur J Pharm Sci. 2017. PMID: 28756205

6

Implications of melanin binding in ocular drug delivery.

Rimpelä AK, Reinisalo M, Hellinen L, Grazhdankin E, Kidron H, Urtti A, Del Amo EM. Rimpelä AK, et al. Among authors: urtti a. Adv Drug Deliv Rev. 2018 Feb 15;126:23-43. doi: 10.1016/j.addr.2017.12.008. Epub 2017 Dec 13. Adv Drug Deliv Rev. 2018. PMID: 29247767 Review.

7

Binding of Small Molecule Drugs to Porcine Vitreous Humor.

Rimpelä AK, Reunanen S, Hagström M, Kidron H, Urtti A. Rimpelä AK, et al. Among authors: urtti a. Mol Pharm. 2018 Jun 4;15(6):2174-2179. doi: 10.1021/acs.molpharmaceut.8b00038. Epub 2018 May 4. Mol Pharm. 2018. PMID: 29648838

8

Influence of Melanin Characteristics on Drug Binding Properties.

Jakubiak P, Lack F, Thun J, Urtti A, Alvarez-Sánchez R. Jakubiak P, et al. Among authors: urtti a. Mol Pharm. 2019 Jun 3;16(6):2549-2556. doi: 10.1021/acs.molpharmaceut.9b00157. Epub 2019 Apr 30. Mol Pharm. 2019. PMID: 30998378

9

Highly hydrophilic 1,3-oxazol-5-yl benzenesulfonamide inhibitors of carbonic anhydrase II for reduction of glaucoma-related intraocular pressure.

Kalinin S, Valtari A, Ruponen M, Toropainen E, Kovalenko A, Nocentini A, Gureev M, Dar'in D, Urtti A, Supuran CT, Krasavin M. Kalinin S, et al. Among authors: urtti a. Bioorg Med Chem. 2019 Nov 1;27(21):115086. doi: 10.1016/j.bmc.2019.115086. Epub 2019 Sep 4. Bioorg Med Chem. 2019. PMID: 31515057

10

Establishment of an In Vitro-In Vivo Correlation for Melanin Binding and the Extension of the Ocular Half-Life of Small-Molecule Drugs.

Jakubiak P, Cantrill C, Urtti A, Alvarez-Sánchez R. Jakubiak P, et al. Among authors: urtti a. Mol Pharm. 2019 Dec 2;16(12):4890-4901. doi: 10.1021/acs.molpharmaceut.9b00769. Epub 2019 Nov 12. Mol Pharm. 2019. PMID: 31670965

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