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Synthesis of 12β-Methyl-18-nor-bile Acids.
ACS Omega. 2021 Sep 14;6(38):25019-25039. doi: 10.1021/acsomega.1c04199. eCollection 2021 Sep 28.
ACS Omega. 2021.
PMID: 34604682
Free PMC article.
C5-Iminosugar modification of casein kinase 1δ lead 3-(4-fluorophenyl)-5-isopropyl-4-(pyridin-4-yl)isoxazole promotes enhanced inhibitor affinity and selectivity.
von Drathen T, Ure EM, Kirschner S, Roth A, Meier L, Woolhouse AD, Cameron SA, Knippschild U, Peifer C, Luxenburger A.
von Drathen T, et al. Among authors: ure em.
Arch Pharm (Weinheim). 2022 May;355(5):e2100497. doi: 10.1002/ardp.202100497. Epub 2022 Feb 17.
Arch Pharm (Weinheim). 2022.
PMID: 35174898
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Synthesis of 12β-methyl-18-nor-avicholic acid analogues as potential TGR5 agonists.
Ure EM, Harris LD, Cameron SA, Weymouth-Wilson A, Furneaux RH, Pitman JL, Hinkley SF, Luxenburger A.
Ure EM, et al.
Org Biomol Chem. 2022 May 4;20(17):3511-3527. doi: 10.1039/d1ob02401a.
Org Biomol Chem. 2022.
PMID: 35230376
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3α,7-Dihydroxy-14(13→12)abeo-5β,12α(H),13β(H)-cholan-24-oic Acids Display Neuroprotective Properties in Common Forms of Parkinson's Disease.
Luxenburger A, Clemmens H, Hastings C, Harris LD, Ure EM, Cameron SA, Aasly J, Bandmann O, Weymouth-Wilson A, Furneaux RH, Mortiboys H.
Luxenburger A, et al. Among authors: ure em.
Biomolecules. 2022 Dec 30;13(1):76. doi: 10.3390/biom13010076.
Biomolecules. 2022.
PMID: 36671460
Free PMC article.
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The discovery of 12β-methyl-17-epi-18-nor-bile acids as potent and selective TGR5 agonists.
Luxenburger A, Harris LD, Ure EM, Jiao W, Woolhouse AD, Cameron SA, Weymouth-Wilson A, Furneaux RH, Pitman JL, Hinkley SFR.
Luxenburger A, et al. Among authors: ure em.
Eur J Med Chem. 2023 Mar 15;250:115143. doi: 10.1016/j.ejmech.2023.115143. Epub 2023 Jan 25.
Eur J Med Chem. 2023.
PMID: 36841086
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