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Identification of activity-based biomarkers for early-stage pancreatic tumors in blood using single-molecule enzyme activity screening.
Sakamoto S, Hiraide H, Minoda M, Iwakura N, Suzuki M, Ando J, Takahashi C, Takahashi I, Murai K, Kagami Y, Mizuno T, Koike T, Nara S, Morizane C, Hijioka S, Kashiro A, Honda K, Watanabe R, Urano Y, Komatsu T. Sakamoto S, et al. Among authors: urano y. Cell Rep Methods. 2024 Jan 22;4(1):100688. doi: 10.1016/j.crmeth.2023.100688. Epub 2024 Jan 12. Cell Rep Methods. 2024. PMID: 38218189 Free PMC article.
Discovery of a cystathionine γ-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5'-phosphate (PLP) via Schiff base formation.
Echizen H, Hanaoka K, Shimamoto K, Hibi R, Toma-Fukai S, Ohno H, Sasaki E, Komatsu T, Ueno T, Tsuchiya Y, Watanabe Y, Otsuka T, Saito H, Nagatoishi S, Tsumoto K, Kojima H, Okabe T, Shimizu T, Urano Y. Echizen H, et al. Among authors: urano y. Sci Rep. 2023 Sep 30;13(1):16456. doi: 10.1038/s41598-023-43536-6. Sci Rep. 2023. PMID: 37777556 Free PMC article.
Senescent cells form nuclear foci that contain the 26S proteasome.
Iriki T, Iio H, Yasuda S, Masuta S, Kato M, Kosako H, Hirayama S, Endo A, Ohtake F, Kamiya M, Urano Y, Saeki Y, Hamazaki J, Murata S. Iriki T, et al. Among authors: urano y. Cell Rep. 2023 Aug 29;42(8):112880. doi: 10.1016/j.celrep.2023.112880. Epub 2023 Aug 3. Cell Rep. 2023. PMID: 37541257 Free article.
Activity-Based Fluorescence Diagnostics for Cancer.
Fujita K, Urano Y. Fujita K, et al. Among authors: urano y. Chem Rev. 2024 Apr 10;124(7):4021-4078. doi: 10.1021/acs.chemrev.3c00612. Epub 2024 Mar 22. Chem Rev. 2024. PMID: 38518254 Review.
523 results