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Single-cell sequencing reveals Hippo signaling as a driver of fibrosis in hidradenitis suppurativa.
van Straalen KR, Ma F, Tsou PS, Plazyo O, Gharaee-Kermani M, Calbet M, Xing X, Sarkar MK, Uppala R, Harms PW, Wasikowski R, Nahlawi L, Nakamura M, Eshaq M, Wang C, Dobry C, Kozlow JH, Cherry-Bukowiec J, Brodie WD, Wolk K, Uluçkan Ö, Mattichak MN, Pellegrini M, Modlin RL, Maverakis E, Sabat R, Kahlenberg JM, Billi AC, Tsoi LC, Gudjonsson JE. van Straalen KR, et al. Among authors: uppala r. J Clin Invest. 2024 Feb 1;134(3):e169225. doi: 10.1172/JCI169225. J Clin Invest. 2024. PMID: 38051587 Free PMC article.
KLK6 expression in skin induces PAR1-mediated psoriasiform dermatitis and inflammatory joint disease.
Billi AC, Ludwig JE, Fritz Y, Rozic R, Swindell WR, Tsoi LC, Gruzska D, Abdollahi-Roodsaz S, Xing X, Diaconu D, Uppala R, Camhi MI, Klenotic PA, Sarkar MK, Husni ME, Scher JU, McDonald C, Kahlenberg JM, Midura RJ, Gudjonsson JE, Ward NL. Billi AC, et al. Among authors: uppala r. J Clin Invest. 2020 Jun 1;130(6):3151-3157. doi: 10.1172/JCI133159. J Clin Invest. 2020. PMID: 32155135 Free PMC article.
IFN-γ enhances cell-mediated cytotoxicity against keratinocytes via JAK2/STAT1 in lichen planus.
Shao S, Tsoi LC, Sarkar MK, Xing X, Xue K, Uppala R, Berthier CC, Zeng C, Patrick M, Billi AC, Fullmer J, Beamer MA, Perez-White B, Getsios S, Schuler A, Voorhees JJ, Choi S, Harms P, Kahlenberg JM, Gudjonsson JE. Shao S, et al. Among authors: uppala r. Sci Transl Med. 2019 Sep 25;11(511):eaav7561. doi: 10.1126/scitranslmed.aav7561. Sci Transl Med. 2019. PMID: 31554739 Free PMC article.
Progression of acute-to-chronic atopic dermatitis is associated with quantitative rather than qualitative changes in cytokine responses.
Tsoi LC, Rodriguez E, Stölzl D, Wehkamp U, Sun J, Gerdes S, Sarkar MK, Hübenthal M, Zeng C, Uppala R, Xing X, Thielking F, Billi AC, Swindell WR, Shefler A, Chen J, Patrick MT, Harms PW, Kahlenberg JM, Perez White BE, Maverakis E, Gudjonsson JE, Weidinger S. Tsoi LC, et al. Among authors: uppala r. J Allergy Clin Immunol. 2020 May;145(5):1406-1415. doi: 10.1016/j.jaci.2019.11.047. Epub 2019 Dec 28. J Allergy Clin Immunol. 2020. PMID: 31891686 Free PMC article.
"Autoinflammatory psoriasis"-genetics and biology of pustular psoriasis.
Uppala R, Tsoi LC, Harms PW, Wang B, Billi AC, Maverakis E, Michelle Kahlenberg J, Ward NL, Gudjonsson JE. Uppala R, et al. Cell Mol Immunol. 2021 Feb;18(2):307-317. doi: 10.1038/s41423-020-0519-3. Epub 2020 Aug 19. Cell Mol Immunol. 2021. PMID: 32814870 Free PMC article. Review.
IRAK2 Has a Critical Role in Promoting Feed-Forward Amplification of Epidermal Inflammatory Responses.
Shao S, Tsoi LC, Swindell WR, Chen J, Uppala R, Billi AC, Xing X, Zeng C, Sarkar MK, Wasikowski R, Jiang Y, Kirma J, Sun J, Plazyo O, Wang G, Harms PW, Voorhees JJ, Ward NL, Ma F, Pellegrini M, Merleev A, Perez White BE, Modlin RL, Andersen B, Maverakis E, Weidinger S, Kahlenberg JM, Gudjonsson JE. Shao S, et al. Among authors: uppala r. J Invest Dermatol. 2021 Oct;141(10):2436-2448. doi: 10.1016/j.jid.2021.03.019. Epub 2021 Apr 15. J Invest Dermatol. 2021. PMID: 33864770 Free PMC article.
Phospholipase A2 enzymes represent a shared pathogenic pathway in psoriasis and pityriasis rubra pilaris.
Shao S, Chen J, Swindell WR, Tsoi LC, Xing X, Ma F, Uppala R, Sarkar MK, Plazyo O, Billi AC, Wasikowski R, Smith KM, Honore P, Scott VE, Maverakis E, Kahlenberg JM, Wang G, Ward NL, Harms PW, Gudjonsson JE. Shao S, et al. Among authors: uppala r. JCI Insight. 2021 Oct 22;6(20):e151911. doi: 10.1172/jci.insight.151911. JCI Insight. 2021. PMID: 34491907 Free PMC article.
Noninvasive Tape-Stripping with High-Resolution RNA Profiling Effectively Captures a Preinflammatory State in Nonlesional Psoriatic Skin.
Tsoi LC, Xing X, Xing E, Wasikowski R, Shao S, Zeng C, Plazyo O, Kirma J, Jiang Y, Billi AC, Sarkar MK, Turnier JL, Uppala R, Smith KM, Helfrich Y, Voorhees JJ, Maverakis E, Modlin RL, Kahlenberg JM, Scott VE, Gudjonsson JE. Tsoi LC, et al. Among authors: uppala r. J Invest Dermatol. 2022 Jun;142(6):1587-1596.e2. doi: 10.1016/j.jid.2021.09.038. Epub 2021 Nov 19. J Invest Dermatol. 2022. PMID: 34808239 Free PMC article.
Photosensitivity and type I IFN responses in cutaneous lupus are driven by epidermal-derived interferon kappa.
Sarkar MK, Hile GA, Tsoi LC, Xing X, Liu J, Liang Y, Berthier CC, Swindell WR, Patrick MT, Shao S, Tsou PS, Uppala R, Beamer MA, Srivastava A, Bielas SL, Harms PW, Getsios S, Elder JT, Voorhees JJ, Gudjonsson JE, Kahlenberg JM. Sarkar MK, et al. Among authors: uppala r. Ann Rheum Dis. 2018 Nov;77(11):1653-1664. doi: 10.1136/annrheumdis-2018-213197. Epub 2018 Jul 18. Ann Rheum Dis. 2018. PMID: 30021804 Free PMC article.
60 results