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IFI16 is an innate immune sensor for intracellular DNA.
Unterholzner L, Keating SE, Baran M, Horan KA, Jensen SB, Sharma S, Sirois CM, Jin T, Latz E, Xiao TS, Fitzgerald KA, Paludan SR, Bowie AG. Unterholzner L, et al. Nat Immunol. 2010 Nov;11(11):997-1004. doi: 10.1038/ni.1932. Epub 2010 Oct 3. Nat Immunol. 2010. PMID: 20890285 Free PMC article.
Innate DNA sensing moves to the nucleus.
Unterholzner L, Bowie AG. Unterholzner L, et al. Cell Host Microbe. 2011 May 19;9(5):351-3. doi: 10.1016/j.chom.2011.05.001. Cell Host Microbe. 2011. PMID: 21575905 Free article.
Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor.
Jin T, Perry A, Jiang J, Smith P, Curry JA, Unterholzner L, Jiang Z, Horvath G, Rathinam VA, Johnstone RW, Hornung V, Latz E, Bowie AG, Fitzgerald KA, Xiao TS. Jin T, et al. Among authors: unterholzner l. Immunity. 2012 Apr 20;36(4):561-71. doi: 10.1016/j.immuni.2012.02.014. Epub 2012 Apr 5. Immunity. 2012. PMID: 22483801 Free PMC article.
Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors.
Horan KA, Hansen K, Jakobsen MR, Holm CK, Søby S, Unterholzner L, Thompson M, West JA, Iversen MB, Rasmussen SB, Ellermann-Eriksen S, Kurt-Jones E, Landolfo S, Damania B, Melchjorsen J, Bowie AG, Fitzgerald KA, Paludan SR. Horan KA, et al. Among authors: unterholzner l. J Immunol. 2013 Mar 1;190(5):2311-9. doi: 10.4049/jimmunol.1202749. Epub 2013 Jan 23. J Immunol. 2013. PMID: 23345332 Free PMC article.
31 results