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Tuning sterol extraction kinetics yields a renal-sparing polyene antifungal.
Nature. 2023 Nov;623(7989):1079-1085. doi: 10.1038/s41586-023-06710-4. Epub 2023 Nov 8.
Nature. 2023.
PMID: 37938782
Free PMC article.
Electronic tuning of site-selectivity.
Wilcock BC, Uno BE, Bromann GL, Clark MJ, Anderson TM, Burke MD.
Wilcock BC, et al. Among authors: uno be.
Nat Chem. 2012 Dec;4(12):996-1003. doi: 10.1038/nchem.1495.
Nat Chem. 2012.
PMID: 23174979
Free PMC article.
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C2'-OH of amphotericin B plays an important role in binding the primary sterol of human cells but not yeast cells.
Wilcock BC, Endo MM, Uno BE, Burke MD.
Wilcock BC, et al. Among authors: uno be.
J Am Chem Soc. 2013 Jun 12;135(23):8488-91. doi: 10.1021/ja403255s. Epub 2013 Jun 3.
J Am Chem Soc. 2013.
PMID: 23718627
Free PMC article.
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Amphotericin forms an extramembranous and fungicidal sterol sponge.
Anderson TM, Clay MC, Cioffi AG, Diaz KA, Hisao GS, Tuttle MD, Nieuwkoop AJ, Comellas G, Maryum N, Wang S, Uno BE, Wildeman EL, Gonen T, Rienstra CM, Burke MD.
Anderson TM, et al. Among authors: uno be.
Nat Chem Biol. 2014 May;10(5):400-6. doi: 10.1038/nchembio.1496. Epub 2014 Mar 30.
Nat Chem Biol. 2014.
PMID: 24681535
Free PMC article.
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Amphotericin primarily kills yeast by simply binding ergosterol.
Gray KC, Palacios DS, Dailey I, Endo MM, Uno BE, Wilcock BC, Burke MD.
Gray KC, et al. Among authors: uno be.
Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2234-9. doi: 10.1073/pnas.1117280109. Epub 2012 Jan 17.
Proc Natl Acad Sci U S A. 2012.
PMID: 22308411
Free PMC article.
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Prodrug Strategies to Improve the Solubility of the HCV NS5A Inhibitor Pibrentasvir (ABT-530).
Randolph JT, Voight EA, Greszler SN, Uno BE, Newton JN, Gleason KM, Stolarik D, Van Handel C, Bow DAJ, DeGoey DA.
Randolph JT, et al. Among authors: uno be.
J Med Chem. 2020 Oct 8;63(19):11034-11044. doi: 10.1021/acs.jmedchem.0c00956. Epub 2020 Sep 17.
J Med Chem. 2020.
PMID: 32881503
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Calcium(ii)-catalyzed enantioselective conjugate additions of amines.
Uno BE, Dicken RD, Redfern LR, Stern CM, Krzywicki GG, Scheidt KA.
Uno BE, et al.
Chem Sci. 2018 Jan 10;9(6):1634-1639. doi: 10.1039/c7sc05205g. eCollection 2018 Feb 14.
Chem Sci. 2018.
PMID: 29675209
Free PMC article.
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