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Increased replication stress and R-loop accumulation in EGFRvIII-expressing glioblastoma present new therapeutic opportunities.
Struve N, Hoffer K, Weik AS, Riepen B, Krug L, Cetin MH, Burmester J, Ott L, Liebing J, Gatzemeier F, Müller-Goebel J, Gerbach M, Bußmann L, Parplys AC, Unger K, Mansour WY, Schüller U, Rieckmann T, Petersen C, Rothkamm K, Short SC, Kriegs M. Struve N, et al. Among authors: unger k. Neurooncol Adv. 2021 Dec 4;4(1):vdab180. doi: 10.1093/noajnl/vdab180. eCollection 2022 Jan-Dec. Neurooncol Adv. 2021. PMID: 35274102 Free PMC article.
Depletion of Histone Demethylase Jarid1A Resulting in Histone Hyperacetylation and Radiation Sensitivity Does Not Affect DNA Double-Strand Break Repair.
Penterling C, Drexler GA, Böhland C, Stamp R, Wilke C, Braselmann H, Caldwell RB, Reindl J, Girst S, Greubel C, Siebenwirth C, Mansour WY, Borgmann K, Dollinger G, Unger K, Friedl AA. Penterling C, et al. Among authors: unger k. PLoS One. 2016 Jun 2;11(6):e0156599. doi: 10.1371/journal.pone.0156599. eCollection 2016. PLoS One. 2016. PMID: 27253695 Free PMC article.
Improved risk stratification in younger IDH wild-type glioblastoma patients by combining a 4-miRNA signature with MGMT promoter methylation status.
Unger K, Fleischmann DF, Ruf V, Felsberg J, Piehlmaier D, Samaga D, Hess J, Suresh MP, Mittelbronn M, Lauber K, Budach W, Sabel M, Rödel C, Reifenberger G, Herms J, Tonn JC, Zitzelsberger H, Belka C, Niyazi M. Unger K, et al. Neurooncol Adv. 2020 Oct 15;2(1):vdaa137. doi: 10.1093/noajnl/vdaa137. eCollection 2020 Jan-Dec. Neurooncol Adv. 2020. PMID: 33305269 Free PMC article.
Inhibition of HSP90 as a Strategy to Radiosensitize Glioblastoma: Targeting the DNA Damage Response and Beyond.
Orth M, Albrecht V, Seidl K, Kinzel L, Unger K, Hess J, Kreutzer L, Sun N, Stegen B, Nieto A, Maas J, Winssinger N, Friedl AA, Walch AK, Belka C, Zitzelsberger H, Niyazi M, Lauber K. Orth M, et al. Among authors: unger k. Front Oncol. 2021 Mar 17;11:612354. doi: 10.3389/fonc.2021.612354. eCollection 2021. Front Oncol. 2021. PMID: 33816244 Free PMC article.
Integrative analysis of therapy resistance and transcriptomic profiling data in glioblastoma cells identifies sensitization vulnerabilities for combined modality radiochemotherapy.
Schnöller LE, Albrecht V, Brix N, Nieto AE, Fleischmann DF, Niyazi M, Hess J, Belka C, Unger K, Lauber K, Orth M. Schnöller LE, et al. Among authors: unger k. Radiat Oncol. 2022 Apr 19;17(1):79. doi: 10.1186/s13014-022-02052-z. Radiat Oncol. 2022. PMID: 35440003 Free PMC article.
A transcriptomic map of EGFR-induced epithelial-to-mesenchymal transition identifies prognostic and therapeutic targets for head and neck cancer.
Schinke H, Shi E, Lin Z, Quadt T, Kranz G, Zhou J, Wang H, Hess J, Heuer S, Belka C, Zitzelsberger H, Schumacher U, Genduso S, Riecken K, Gao Y, Wu Z, Reichel CA, Walz C, Canis M, Unger K, Baumeister P, Pan M, Gires O. Schinke H, et al. Among authors: unger k. Mol Cancer. 2022 Sep 8;21(1):178. doi: 10.1186/s12943-022-01646-1. Mol Cancer. 2022. PMID: 36076232 Free PMC article.
Systematic in vitro analysis of therapy resistance in glioblastoma cell lines by integration of clonogenic survival data with multi-level molecular data.
Schnöller LE, Piehlmaier D, Weber P, Brix N, Fleischmann DF, Nieto AE, Selmansberger M, Heider T, Hess J, Niyazi M, Belka C, Lauber K, Unger K, Orth M. Schnöller LE, et al. Among authors: unger k. Radiat Oncol. 2023 Mar 11;18(1):51. doi: 10.1186/s13014-023-02241-4. Radiat Oncol. 2023. PMID: 36906590 Free PMC article.
A 4-miRNA signature predicts the therapeutic outcome of glioblastoma.
Niyazi M, Pitea A, Mittelbronn M, Steinbach J, Sticht C, Zehentmayr F, Piehlmaier D, Zitzelsberger H, Ganswindt U, Rödel C, Lauber K, Belka C, Unger K. Niyazi M, et al. Among authors: unger k. Oncotarget. 2016 Jul 19;7(29):45764-45775. doi: 10.18632/oncotarget.9945. Oncotarget. 2016. PMID: 27302927 Free PMC article.
427 results