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Discovery and pharmacological evaluation of indole derivatives as potent and selective RORγt inverse agonist for multiple autoimmune conditions.
Shaikh NS, Iyer JP, Munot YS, Mukhopadhyay PP, Raje AA, Nagaraj R, Jamdar V, Gavhane R, Lohote M, Sherkar P, Bala M, Petla R, Meru A, Umrani D, Rouduri S, Joshi S, Reddy S, Kandikere V, Bhuniya D, Kulkarni B, Mookhtiar KA. Shaikh NS, et al. Among authors: umrani d. Bioorg Med Chem Lett. 2019 Aug 15;29(16):2208-2217. doi: 10.1016/j.bmcl.2019.06.044. Epub 2019 Jun 22. Bioorg Med Chem Lett. 2019. PMID: 31272795
Discovery of a potent and selective small molecule hGPR91 antagonist.
Bhuniya D, Umrani D, Dave B, Salunke D, Kukreja G, Gundu J, Naykodi M, Shaikh NS, Shitole P, Kurhade S, De S, Majumdar S, Reddy SB, Tambe S, Shejul Y, Chugh A, Palle VP, Mookhtiar KA, Cully D, Vacca J, Chakravarty PK, Nargund RP, Wright SD, Graziano MP, Singh SB, Roy S, Cai TQ. Bhuniya D, et al. Among authors: umrani d. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3596-602. doi: 10.1016/j.bmcl.2011.04.091. Epub 2011 Apr 28. Bioorg Med Chem Lett. 2011. PMID: 21571530
Discovery and evaluation of 1H-pyrrolo[2,3-b]pyridine based selective and reversible small molecule BTK inhibitors for the treatment of rheumatoid arthritis.
Thakkar M, Bhuniya D, Kaduskar R, Mengawade T, Naik K, Salunkhe V, Bhalerao A, Kurhade S, Mavinahalli J, Jain V, Petla R, Avaragolla S, Ray S, Rouduri S, Dhanave A, De S, Pathade V, Tambe A, Raje AA, Madgula V, Joshi S, Nadeem A, Bala M, Umrani D, Hariharan N, Kulkarni B, Mookhtiar KA. Thakkar M, et al. Among authors: umrani d. Bioorg Med Chem Lett. 2017 Apr 15;27(8):1867-1873. doi: 10.1016/j.bmcl.2017.02.026. Epub 2017 Feb 22. Bioorg Med Chem Lett. 2017. PMID: 28279528
Discovery of liver-directed glucokinase activator having anti-hyperglycemic effect without hypoglycemia.
Deshpande AM, Bhuniya D, De S, Dave B, Vyavahare VP, Kurhade SH, Kandalkar SR, Naik KP, Kobal BS, Kaduskar RD, Basu S, Jain V, Patil P, Chaturvedi Joshi S, Bhat G, Raje AA, Reddy S, Gundu J, Madgula V, Tambe S, Shitole P, Umrani D, Chugh A, Palle VP, Mookhtiar KA. Deshpande AM, et al. Among authors: umrani d. Eur J Med Chem. 2017 Jun 16;133:268-286. doi: 10.1016/j.ejmech.2017.03.042. Epub 2017 Mar 24. Eur J Med Chem. 2017. PMID: 28390958
Design and synthesis of novel spirocyclic carboxylic acids as potent and orally bioavailable DGAT1 inhibitors and their biological evaluation.
Koul S, Kurhade S, Bhosale S, Naik K, Salunkhe V, Ravula S, Punde P, Velayutham R, Tiwari A, Ahl D, Malkapuram S, Mudagala V, Raje A, Umrani D, Tambe S, Patil P, Singh U, Bhuniya D, Hariharan N, Mookhtiar K. Koul S, et al. Among authors: umrani d. Bioorg Med Chem Lett. 2022 Apr 15;62:128632. doi: 10.1016/j.bmcl.2022.128632. Epub 2022 Feb 18. Bioorg Med Chem Lett. 2022. PMID: 35189320
16 results