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Conophylline inhibits non-alcoholic steatohepatitis in mice.
Nakade Y, Sakamoto K, Yamauchi T, Inoue T, Kobayashi Y, Yamamoto T, Ishii N, Ohashi T, Sumida Y, Ito K, Nakao H, Fukuzawa Y, Umezawa K, Yoneda M. Nakade Y, et al. Among authors: umezawa k. PLoS One. 2017 Jun 8;12(6):e0178436. doi: 10.1371/journal.pone.0178436. eCollection 2017. PLoS One. 2017. PMID: 28594915 Free PMC article.
Conophylline suppresses pancreatic cancer desmoplasia and cancer-promoting cytokines produced by cancer-associated fibroblasts.
Ishii N, Araki K, Yokobori T, Hagiwara K, Gantumur D, Yamanaka T, Handa T, Tsukagoshi M, Igarashi T, Watanabe A, Kubo N, Harimoto N, Masamune A, Umezawa K, Kuwano H, Shirabe K. Ishii N, et al. Among authors: umezawa k. Cancer Sci. 2019 Jan;110(1):334-344. doi: 10.1111/cas.13847. Epub 2018 Dec 13. Cancer Sci. 2019. PMID: 30353606 Free PMC article.
The plant alkaloid conophylline inhibits matrix formation of fibroblasts.
Tezuka T, Ota A, Karnan S, Matsuura K, Yokoo K, Hosokawa Y, Vigetti D, Passi A, Hatano S, Umezawa K, Watanabe H. Tezuka T, et al. Among authors: umezawa k. J Biol Chem. 2018 Dec 28;293(52):20214-20226. doi: 10.1074/jbc.RA118.005783. Epub 2018 Oct 30. J Biol Chem. 2018. PMID: 30377255 Free PMC article.
Conophylline inhibits high fat diet-induced non-alcoholic fatty liver disease in mice.
Ohashi T, Nakade Y, Ibusuki M, Kitano R, Yamauchi T, Kimoto S, Inoue T, Kobayashi Y, Sumida Y, Ito K, Nakao H, Umezawa K, Yoneda M. Ohashi T, et al. Among authors: umezawa k. PLoS One. 2019 Jan 28;14(1):e0210068. doi: 10.1371/journal.pone.0210068. eCollection 2019. PLoS One. 2019. PMID: 30689650 Free PMC article.
Conophylline Inhibits Hepatocellular Carcinoma by Inhibiting Activated Cancer-associated Fibroblasts Through Suppression of G Protein-coupled Receptor 68.
Yamanaka T, Harimoto N, Yokobori T, Muranushi R, Hoshino K, Hagiwara K, Gantumur D, Handa T, Ishii N, Tsukagoshi M, Igarashi T, Watanabe A, Kubo N, Araki K, Umezawa K, Shirabe K. Yamanaka T, et al. Among authors: umezawa k. Mol Cancer Ther. 2021 Jun;20(6):1019-1028. doi: 10.1158/1535-7163.MCT-20-0150. Epub 2021 Mar 15. Mol Cancer Ther. 2021. PMID: 33722852
638 results