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SLITRK2 variants associated with neurodevelopmental disorders impair excitatory synaptic function and cognition in mice.
El Chehadeh S, Han KA, Kim D, Jang G, Bakhtiari S, Lim D, Kim HY, Kim J, Kim H, Wynn J, Chung WK, Vitiello G, Cutcutache I, Page M, Gecz J, Harper K, Han AR, Kim HM, Wessels M, Bayat A, Jaén AF, Selicorni A, Maitz S, de Brouwer APM, Silfhout AV, Armstrong M, Symonds J, Küry S, Isidor B, Cogné B, Nizon M, Feger C, Muller J, Torti E, Grange DK, Willems M, Kruer MC, Ko J, Piton A, Um JW. El Chehadeh S, et al. Among authors: um jw. Nat Commun. 2022 Jul 15;13(1):4112. doi: 10.1038/s41467-022-31566-z. Nat Commun. 2022. PMID: 35840571 Free PMC article.
PTPσ functions as a presynaptic receptor for the glypican-4/LRRTM4 complex and is essential for excitatory synaptic transmission.
Ko JS, Pramanik G, Um JW, Shim JS, Lee D, Kim KH, Chung GY, Condomitti G, Kim HM, Kim H, de Wit J, Park KS, Tabuchi K, Ko J. Ko JS, et al. Among authors: um jw. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1874-9. doi: 10.1073/pnas.1410138112. Epub 2015 Jan 26. Proc Natl Acad Sci U S A. 2015. PMID: 25624497 Free PMC article.
The balancing act of GABAergic synapse organizers.
Ko J, Choii G, Um JW. Ko J, et al. Among authors: um jw. Trends Mol Med. 2015 Apr;21(4):256-68. doi: 10.1016/j.molmed.2015.01.004. Trends Mol Med. 2015. PMID: 25824541 Review.
Emergent Synapse Organizers: LAR-RPTPs and Their Companions.
Han KA, Jeon S, Um JW, Ko J. Han KA, et al. Among authors: um jw. Int Rev Cell Mol Biol. 2016;324:39-65. doi: 10.1016/bs.ircmb.2016.01.002. Epub 2016 Feb 8. Int Rev Cell Mol Biol. 2016. PMID: 27017006 Review.
110 results