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A self-amplifying mRNA SARS-CoV-2 vaccine candidate induces safe and robust protective immunity in preclinical models.
Maruggi G, Mallett CP, Westerbeck JW, Chen T, Lofano G, Friedrich K, Qu L, Sun JT, McAuliffe J, Kanitkar A, Arrildt KT, Wang KF, McBee I, McCoy D, Terry R, Rowles A, Abrahim MA, Ringenberg MA, Gains MJ, Spickler C, Xie X, Zou J, Shi PY, Dutt T, Henao-Tamayo M, Ragan I, Bowen RA, Johnson R, Nuti S, Luisi K, Ulmer JB, Steff AM, Jalah R, Bertholet S, Stokes AH, Yu D. Maruggi G, et al. Among authors: ulmer jb. Mol Ther. 2022 May 4;30(5):1897-1912. doi: 10.1016/j.ymthe.2022.01.001. Epub 2022 Jan 3. Mol Ther. 2022. PMID: 34990810 Free PMC article. Clinical Trial.
Mechanism of action of mRNA-based vaccines.
Iavarone C, O'hagan DT, Yu D, Delahaye NF, Ulmer JB. Iavarone C, et al. Among authors: ulmer jb. Expert Rev Vaccines. 2017 Sep;16(9):871-881. doi: 10.1080/14760584.2017.1355245. Epub 2017 Jul 28. Expert Rev Vaccines. 2017. PMID: 28701102 Review.
Development of a potent Zika virus vaccine using self-amplifying messenger RNA.
Luisi K, Morabito KM, Burgomaster KE, Sharma M, Kong WP, Foreman BM, Patel S, Fisher B, Aleshnick MA, Laliberte J, Wallace M, Ruckwardt TJ, Gordon DN, Linton C, Ruggiero N, Cohen JL, Johnson R, Aggarwal K, Ko SY, Yang ES, Pelc RS, Dowd KA, O'Hagan D, Ulmer J, Mossman S, Sambor A, Lepine E, Mascola JR, Pierson TC, Graham BS, Yu D. Luisi K, et al. Sci Adv. 2020 Aug 7;6(32):eaba5068. doi: 10.1126/sciadv.aba5068. eCollection 2020 Aug. Sci Adv. 2020. PMID: 32821824 Free PMC article.
Self-amplifying mRNA vaccines.
Brito LA, Kommareddy S, Maione D, Uematsu Y, Giovani C, Berlanda Scorza F, Otten GR, Yu D, Mandl CW, Mason PW, Dormitzer PR, Ulmer JB, Geall AJ. Brito LA, et al. Among authors: ulmer jb. Adv Genet. 2015;89:179-233. doi: 10.1016/bs.adgen.2014.10.005. Epub 2014 Dec 4. Adv Genet. 2015. PMID: 25620012
A cationic nanoemulsion for the delivery of next-generation RNA vaccines.
Brito LA, Chan M, Shaw CA, Hekele A, Carsillo T, Schaefer M, Archer J, Seubert A, Otten GR, Beard CW, Dey AK, Lilja A, Valiante NM, Mason PW, Mandl CW, Barnett SW, Dormitzer PR, Ulmer JB, Singh M, O'Hagan DT, Geall AJ. Brito LA, et al. Among authors: ulmer jb. Mol Ther. 2014 Dec;22(12):2118-2129. doi: 10.1038/mt.2014.133. Epub 2014 Jul 16. Mol Ther. 2014. PMID: 25027661 Free PMC article.
Recent innovations in mRNA vaccines.
Ulmer JB, Geall AJ. Ulmer JB, et al. Curr Opin Immunol. 2016 Aug;41:18-22. doi: 10.1016/j.coi.2016.05.008. Epub 2016 May 26. Curr Opin Immunol. 2016. PMID: 27240054 Review.
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