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Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome.
Deni I, Stokes BH, Ward KE, Fairhurst KJ, Pasaje CFA, Yeo T, Akbar S, Park H, Muir R, Bick DS, Zhan W, Zhang H, Liu YJ, Ng CL, Kirkman LA, Almaliti J, Gould AE, Duffey M, O'Donoghue AJ, Uhlemann AC, Niles JC, da Fonseca PCA, Gerwick WH, Lin G, Bogyo M, Fidock DA. Deni I, et al. Among authors: uhlemann ac. Cell Chem Biol. 2023 May 18;30(5):470-485.e6. doi: 10.1016/j.chembiol.2023.03.002. Epub 2023 Mar 23. Cell Chem Biol. 2023. PMID: 36963402 Free PMC article.
Capsular Polysaccharide Is Essential for the Virulence of the Antimicrobial-Resistant Pathogen Enterobacter hormaechei.
St John A, Perault AI, Giacometti SI, Sommerfield AG, DuMont AL, Lacey KA, Zheng X, Sproch J, Petzold C, Dancel-Manning K, Gonzalez S, Annavajhala M, Beckford C, Zeitouni N, Liang FX, van Bakel H, Shopsin B, Uhlemann AC, Pironti A, Torres VJ. St John A, et al. Among authors: uhlemann ac. mBio. 2023 Apr 25;14(2):e0259022. doi: 10.1128/mbio.02590-22. Epub 2023 Feb 13. mBio. 2023. PMID: 36779722 Free PMC article.
Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness.
Mok S, Yeo T, Hong D, Shears MJ, Ross LS, Ward KE, Dhingra SK, Kanai M, Bridgford JL, Tripathi AK, Mlambo G, Burkhard AY, Ansbro MR, Fairhurst KJ, Gil-Iturbe E, Park H, Rozenberg FD, Kim J, Mancia F, Fairhurst RM, Quick M, Uhlemann AC, Sinnis P, Fidock DA. Mok S, et al. Among authors: uhlemann ac. Sci Adv. 2023 Nov 10;9(45):eadi2364. doi: 10.1126/sciadv.adi2364. Epub 2023 Nov 8. Sci Adv. 2023. PMID: 37939186 Free PMC article.
193 results