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Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatohepatitis.
Kawamura S, Matsushita Y, Kurosaki S, Tange M, Fujiwara N, Hayata Y, Hayakawa Y, Suzuki N, Hata M, Tsuboi M, Kishikawa T, Kinoshita H, Nakatsuka T, Sato M, Kudo Y, Hoshida Y, Umemura A, Eguchi A, Ikenoue T, Hirata Y, Uesugi M, Tateishi R, Tateishi K, Fujishiro M, Koike K, Nakagawa H. Kawamura S, et al. Among authors: uesugi m. J Clin Invest. 2022 Jun 1;132(11):e151895. doi: 10.1172/JCI151895. J Clin Invest. 2022. PMID: 35380992 Free PMC article.
A small molecule that blocks fat synthesis by inhibiting the activation of SREBP.
Kamisuki S, Mao Q, Abu-Elheiga L, Gu Z, Kugimiya A, Kwon Y, Shinohara T, Kawazoe Y, Sato S, Asakura K, Choo HY, Sakai J, Wakil SJ, Uesugi M. Kamisuki S, et al. Among authors: uesugi m. Chem Biol. 2009 Aug 28;16(8):882-92. doi: 10.1016/j.chembiol.2009.07.007. Chem Biol. 2009. PMID: 19716478 Free article.
Nutrient-Based Chemical Library as a Source of Energy Metabolism Modulators.
Furuta T, Mizukami Y, Asano L, Kotake K, Ziegler S, Yoshida H, Watanabe M, Sato SI, Waldmann H, Nishikawa M, Uesugi M. Furuta T, et al. Among authors: uesugi m. ACS Chem Biol. 2019 Sep 20;14(9):1860-1865. doi: 10.1021/acschembio.9b00444. Epub 2019 Aug 26. ACS Chem Biol. 2019. PMID: 31436407 Free article.
Controlled lipid β-oxidation and carnitine biosynthesis by a vitamin D metabolite.
Mendoza A, Takemoto Y, Cruzado KT, Masoud SS, Nagata A, Tantipanjaporn A, Okuda S, Kawagoe F, Sakamoto R, Odagi M, Mototani S, Togashi M, Kawatani M, Aono H, Osada H, Nakagawa H, Higashi T, Kittaka A, Nagasawa K, Uesugi M. Mendoza A, et al. Among authors: uesugi m. Cell Chem Biol. 2022 Apr 21;29(4):660-669.e12. doi: 10.1016/j.chembiol.2021.08.008. Epub 2021 Sep 9. Cell Chem Biol. 2022. PMID: 34506728 Free article.
Synthetic Chemical Probes That Dissect Vitamin D Activities.
Nagata A, Akagi Y, Asano L, Kotake K, Kawagoe F, Mendoza A, Masoud SS, Usuda K, Yasui K, Takemoto Y, Kittaka A, Nagasawa K, Uesugi M. Nagata A, et al. Among authors: uesugi m. ACS Chem Biol. 2019 Dec 20;14(12):2851-2858. doi: 10.1021/acschembio.9b00718. Epub 2019 Oct 28. ACS Chem Biol. 2019. PMID: 31618573 Free article.
300 results