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Defective domain-domain interactions within the ryanodine receptor as a critical cause of diastolic Ca2+ leak in failing hearts.
Tateishi H, Yano M, Mochizuki M, Suetomi T, Ono M, Xu X, Uchinoumi H, Okuda S, Oda T, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, Ikemoto N, Matsuzaki M. Tateishi H, et al. Among authors: uchinoumi h. Cardiovasc Res. 2009 Feb 15;81(3):536-45. doi: 10.1093/cvr/cvn303. Epub 2008 Nov 7. Cardiovasc Res. 2009. PMID: 18996969 Free PMC article.
Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing interdomain interactions within the ryanodine receptor.
Kobayashi S, Yano M, Suetomi T, Ono M, Tateishi H, Mochizuki M, Xu X, Uchinoumi H, Okuda S, Yamamoto T, Koseki N, Kyushiki H, Ikemoto N, Matsuzaki M. Kobayashi S, et al. Among authors: uchinoumi h. J Am Coll Cardiol. 2009 May 26;53(21):1993-2005. doi: 10.1016/j.jacc.2009.01.065. J Am Coll Cardiol. 2009. PMID: 19460614 Free PMC article.
Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction.
Xu X, Yano M, Uchinoumi H, Hino A, Suetomi T, Ono M, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Ikeda Y, Ikemoto N, Matsuzaki M. Xu X, et al. Among authors: uchinoumi h. Biochem Biophys Res Commun. 2010 Apr 9;394(3):660-6. doi: 10.1016/j.bbrc.2010.03.046. Epub 2010 Mar 10. Biochem Biophys Res Commun. 2010. PMID: 20226167 Free PMC article.
Dantrolene, a therapeutic agent for malignant hyperthermia, inhibits catecholaminergic polymorphic ventricular tachycardia in a RyR2(R2474S/+) knock-in mouse model.
Kobayashi S, Yano M, Uchinoumi H, Suetomi T, Susa T, Ono M, Xu X, Tateishi H, Oda T, Okuda S, Doi M, Yamamoto T, Matsuzaki M. Kobayashi S, et al. Among authors: uchinoumi h. Circ J. 2010 Nov;74(12):2579-84. doi: 10.1253/circj.cj-10-0680. Epub 2010 Oct 7. Circ J. 2010. PMID: 20944434 Free article.
Mutation-linked defective interdomain interactions within ryanodine receptor cause aberrant Ca²⁺release leading to catecholaminergic polymorphic ventricular tachycardia.
Suetomi T, Yano M, Uchinoumi H, Fukuda M, Hino A, Ono M, Xu X, Tateishi H, Okuda S, Doi M, Kobayashi S, Ikeda Y, Yamamoto T, Ikemoto N, Matsuzaki M. Suetomi T, et al. Among authors: uchinoumi h. Circulation. 2011 Aug 9;124(6):682-94. doi: 10.1161/CIRCULATIONAHA.111.023259. Epub 2011 Jul 18. Circulation. 2011. PMID: 21768539 Free PMC article.
A low-dose β1-blocker in combination with milrinone improves intracellular Ca2+ handling in failing cardiomyocytes by inhibition of milrinone-induced diastolic Ca2+ leakage from the sarcoplasmic reticulum.
Kobayashi S, Susa T, Ishiguchi H, Myoren T, Murakami W, Kato T, Fukuda M, Hino A, Suetomi T, Ono M, Uchinoumi H, Tateishi H, Mochizuki M, Oda T, Okuda S, Doi M, Yamamoto T, Yano M. Kobayashi S, et al. Among authors: uchinoumi h. PLoS One. 2015 Jan 23;10(1):e0114314. doi: 10.1371/journal.pone.0114314. eCollection 2015. PLoS One. 2015. PMID: 25614983 Free PMC article.
39 results