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Extracellular endosulfatase Sulf-2 harbors a chondroitin/dermatan sulfate chain that modulates its enzyme activity.
El Masri R, Seffouh A, Roelants C, Seffouh I, Gout E, Pérard J, Dalonneau F, Nishitsuji K, Noborn F, Nikpour M, Larson G, Crétinon Y, Friedel-Arboleas M, Uchimura K, Daniel R, Lortat-Jacob H, Filhol O, Vivès RR. El Masri R, et al. Among authors: uchimura k. Cell Rep. 2022 Mar 15;38(11):110516. doi: 10.1016/j.celrep.2022.110516. Cell Rep. 2022. PMID: 35294879 Free article.
Heparan sulfate subdomains that are degraded by Sulf accumulate in cerebral amyloid ß plaques of Alzheimer's disease: evidence from mouse models and patients.
Hosono-Fukao T, Ohtake-Niimi S, Hoshino H, Britschgi M, Akatsu H, Hossain MM, Nishitsuji K, van Kuppevelt TH, Kimata K, Michikawa M, Wyss-Coray T, Uchimura K. Hosono-Fukao T, et al. Among authors: uchimura k. Am J Pathol. 2012 May;180(5):2056-67. doi: 10.1016/j.ajpath.2012.01.015. Epub 2012 Mar 17. Am J Pathol. 2012. PMID: 22429964
Iowa Mutant Apolipoprotein A-I (ApoA-IIowa) Fibrils Target Lysosomes.
Kameyama H, Nakajima H, Nishitsuji K, Mikawa S, Uchimura K, Kobayashi N, Okuhira K, Saito H, Sakashita N. Kameyama H, et al. Among authors: uchimura k. Sci Rep. 2016 Jul 28;6:30391. doi: 10.1038/srep30391. Sci Rep. 2016. PMID: 27464946 Free PMC article.
The Accumulation of Heparan Sulfate S-Domains in Kidney Transthyretin Deposits Accelerates Fibril Formation and Promotes Cytotoxicity.
Kameyama H, Uchimura K, Yamashita T, Kuwabara K, Mizuguchi M, Hung SC, Okuhira K, Masuda T, Kosugi T, Ohgita T, Saito H, Ando Y, Nishitsuji K. Kameyama H, et al. Among authors: uchimura k. Am J Pathol. 2019 Feb;189(2):308-319. doi: 10.1016/j.ajpath.2018.09.015. Epub 2018 Nov 7. Am J Pathol. 2019. PMID: 30414409 Free article.
A novel amphipathic cell-penetrating peptide based on the N-terminal glycosaminoglycan binding region of human apolipoprotein E.
Ohgita T, Takechi-Haraya Y, Nadai R, Kotani M, Tamura Y, Nishikiori K, Nishitsuji K, Uchimura K, Hasegawa K, Sakai-Kato K, Akaji K, Saito H. Ohgita T, et al. Among authors: uchimura k. Biochim Biophys Acta Biomembr. 2019 Mar 1;1861(3):541-549. doi: 10.1016/j.bbamem.2018.12.010. Epub 2018 Dec 15. Biochim Biophys Acta Biomembr. 2019. PMID: 30562499 Free article.
Enhancement of direct membrane penetration of arginine-rich peptides by polyproline II helix structure.
Ohgita T, Takechi-Haraya Y, Okada K, Matsui S, Takeuchi M, Saito C, Nishitsuji K, Uchimura K, Kawano R, Hasegawa K, Sakai-Kato K, Akaji K, Izutsu KI, Saito H. Ohgita T, et al. Among authors: uchimura k. Biochim Biophys Acta Biomembr. 2020 Oct 1;1862(10):183403. doi: 10.1016/j.bbamem.2020.183403. Epub 2020 Jun 23. Biochim Biophys Acta Biomembr. 2020. PMID: 32585206 Free article.
337 results