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Blood-brain barrier (BBB) pharmacoproteomics: reconstruction of in vivo brain distribution of 11 P-glycoprotein substrates based on the BBB transporter protein concentration, in vitro intrinsic transport activity, and unbound fraction in plasma and brain in mice.
Uchida Y, Ohtsuki S, Kamiie J, Terasaki T. Uchida Y, et al. J Pharmacol Exp Ther. 2011 Nov;339(2):579-88. doi: 10.1124/jpet.111.184200. Epub 2011 Aug 9. J Pharmacol Exp Ther. 2011. PMID: 21828264
Quantitative targeted absolute proteomic analysis of transporters, receptors and junction proteins for validation of human cerebral microvascular endothelial cell line hCMEC/D3 as a human blood-brain barrier model.
Ohtsuki S, Ikeda C, Uchida Y, Sakamoto Y, Miller F, Glacial F, Decleves X, Scherrmann JM, Couraud PO, Kubo Y, Tachikawa M, Terasaki T. Ohtsuki S, et al. Among authors: uchida y. Mol Pharm. 2013 Jan 7;10(1):289-96. doi: 10.1021/mp3004308. Epub 2012 Dec 11. Mol Pharm. 2013. PMID: 23137377
A study protocol for quantitative targeted absolute proteomics (QTAP) by LC-MS/MS: application for inter-strain differences in protein expression levels of transporters, receptors, claudin-5, and marker proteins at the blood-brain barrier in ddY, FVB, and C57BL/6J mice.
Uchida Y, Tachikawa M, Obuchi W, Hoshi Y, Tomioka Y, Ohtsuki S, Terasaki T. Uchida Y, et al. Fluids Barriers CNS. 2013 Jun 8;10(1):21. doi: 10.1186/2045-8118-10-21. Fluids Barriers CNS. 2013. PMID: 23758935 Free PMC article.
2,689 results