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Biomarker-focused multi-drug combination therapy and repurposing trial in mdx mice.
Ziemba M, Barkhouse M, Uaesoontrachoon K, Giri M, Hathout Y, Dang UJ, Gordish-Dressman H, Nagaraju K, Hoffman EP. Ziemba M, et al. Among authors: uaesoontrachoon k. PLoS One. 2021 Feb 22;16(2):e0246507. doi: 10.1371/journal.pone.0246507. eCollection 2021. PLoS One. 2021. PMID: 33617542 Free PMC article.
Ryanodine channel complex stabilizer compound S48168/ARM210 as a disease modifier in dystrophin-deficient mdx mice: proof-of-concept study and independent validation of efficacy.
Capogrosso RF, Mantuano P, Uaesoontrachoon K, Cozzoli A, Giustino A, Dow T, Srinivassane S, Filipovic M, Bell C, Vandermeulen J, Massari AM, De Bellis M, Conte E, Pierno S, Camerino GM, Liantonio A, Nagaraju K, De Luca A. Capogrosso RF, et al. Among authors: uaesoontrachoon k. FASEB J. 2018 Feb;32(2):1025-1043. doi: 10.1096/fj.201700182RRR. Epub 2018 Jan 3. FASEB J. 2018. PMID: 29097503 Free PMC article.
Vamorolone targets dual nuclear receptors to treat inflammation and dystrophic cardiomyopathy.
Heier CR, Yu Q, Fiorillo AA, Tully CB, Tucker A, Mazala DA, Uaesoontrachoon K, Srinivassane S, Damsker JM, Hoffman EP, Nagaraju K, Spurney CF. Heier CR, et al. Among authors: uaesoontrachoon k. Life Sci Alliance. 2019 Feb 11;2(1):e201800186. doi: 10.26508/lsa.201800186. Print 2019 Feb. Life Sci Alliance. 2019. PMID: 30745312 Free PMC article.
VBP15, a glucocorticoid analogue, is effective at reducing allergic lung inflammation in mice.
Damsker JM, Dillingham BC, Rose MC, Balsley MA, Heier CR, Watson AM, Stemmy EJ, Jurjus RA, Huynh T, Tatem K, Uaesoontrachoon K, Berry DM, Benton AS, Freishtat RJ, Hoffman EP, McCall JM, Gordish-Dressman H, Constant SL, Reeves EK, Nagaraju K. Damsker JM, et al. Among authors: uaesoontrachoon k. PLoS One. 2013 May 7;8(5):e63871. doi: 10.1371/journal.pone.0063871. Print 2013. PLoS One. 2013. PMID: 23667681 Free PMC article.
Orthogonal analysis of dystrophin protein and mRNA as a surrogate outcome for drug development.
Uaesoontrachoon K, Srinivassane S, Warford J, Mekhssian K, Montpetit H, Beauvois R, Keyhani A, Hathout Y, Yamashita T, Satou Y, Osaki H, Praest M, Moraca M, Malbasic M, Ross W, MacKinnon A, Rowsell J, Mullen A, Matyas M, Mummidivarpu S, Nagaraju K, Hoffman EP. Uaesoontrachoon K, et al. Biomark Med. 2019 Oct;13(14):1209-1225. doi: 10.2217/bmm-2019-0242. Epub 2019 Aug 5. Biomark Med. 2019. PMID: 31379197 Free article.
TNF-α-Induced microRNAs Control Dystrophin Expression in Becker Muscular Dystrophy.
Fiorillo AA, Heier CR, Novak JS, Tully CB, Brown KJ, Uaesoontrachoon K, Vila MC, Ngheim PP, Bello L, Kornegay JN, Angelini C, Partridge TA, Nagaraju K, Hoffman EP. Fiorillo AA, et al. Among authors: uaesoontrachoon k. Cell Rep. 2015 Sep 8;12(10):1678-90. doi: 10.1016/j.celrep.2015.07.066. Epub 2015 Aug 28. Cell Rep. 2015. PMID: 26321630 Free PMC article.
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